Recent Submissions

  • The Nereid on the rise: Platynereis as a model system 

    Ozpolat, B. Duygu; Randel, Nadine; Williams, Elizabeth A.; Bezares-Calderón, Luis Alberto; Andreatta, Gabriele; Balavoine, Guillaume; Bertucci, Paola Y.; Ferrier, David E. K.; Gambi, Maria Cristina; Gazave, Eve; Handberg-Thorsager, Mette; Hardege, Jörg; Hird, Cameron; Hsieh, Yu-Wen; Hui, Jerome; Mutemi, Kevin Nzumbi; Schneider, Stephan Q.; Simakov, Oleg; Vergara, Hernando M.; Vervoort, Michel; Jékely, Gáspár; Tessmar-Raible, Kristin; Raible, Florian; Arendt, Detlev (BMC, 2021-09-27)
    The Nereid Platynereis dumerilii (Audouin and Milne Edwards (Annales des Sciences Naturelles 1:195–269, 1833) is a marine annelid that belongs to the Nereididae, a family of errant polychaete worms. The Nereid shows a ...
  • Explaining regeneration: cells and limbs as complex living systems, learning from history 

    MacCord, Kate; Maienschein, Jane (Frontiers Media, 2021-08-31)
    Regeneration has been investigated since Aristotle, giving rise to many ways of explaining what this process is and how it works. Current research focuses on gene expression and cell signaling of regeneration within ...
  • Real-time polarization microscopy of fibrillar collagen in histopathology 

    Keikhosravi, Adib; Shribak, Michael; Conklin, Matthew W.; Liu, Yuming; Li, Bin; Loeffler, Agnes; Levenson, Richard; Eliceiri, Kevin (Nature Research, 2021-09-24)
    Over the past two decades, fibrillar collagen reorganization parameters such as the amount of collagen deposition, fiber angle and alignment have been widely explored in numerous studies. These parameters are now widely ...
  • Asynchronous release sites align with NMDA receptors in mouse hippocampal synapses 

    Li, Shuo; Raychaudhuri, Sumana; Lee, Stephen Alexander; Brockmann, Marisa M.; Wang, Jing; Kusick, Grant; Prater, Christine; Syed, Sarah; Falahati, Hanieh; Ramos, Raul; Bartol, Tomas M.; Hosy, Eric; Watanabe, Shigeki (Nature Research, 2021-01-29)
    Neurotransmitter is released synchronously and asynchronously following an action potential. Our recent study indicates that the release sites of these two phases are segregated within an active zone, with asynchronous ...
  • Emerging wetlands from river diversions can sustain high denitrification rates in a Coastal Delta 

    Upreti, Kiran; Rivera-Monroy, Victor H.; Maiti, Kanchan; Giblin, Anne E.; Geaghan, James P. (American Geophysical Union, 2021-03-31)
    It is assumed that to treat excess NO3− high soil organic matter content (%OM) is required to maintain high denitrification rates in natural or restored wetlands. However, this excess also represents a risk by increasing ...
  • A genetically encoded tool for reconstituting synthetic modulatory neurotransmission and reconnect neural circuits in vivo 

    Hawk, Josh D.; Wisdom, Elias M.; Sengupta, Titas; Kashlan, Zane D.; Colón-Ramos, Daniel (Nature Research, 2021-08-09)
    Chemogenetic and optogenetic tools have transformed the field of neuroscience by facilitating the examination and manipulation of existing circuits. Yet, the field lacks tools that enable rational rewiring of circuits via ...
  • Understanding the effects of climate change via disturbance on pristine arctic lakes-multitrophic level response and recovery to a 12-yr, low-level fertilization experiment 

    Budy, Phaedra; Pennock, Casey A.; Giblin, Anne E.; Luecke, Chris; White, Daniel L.; Kling, George W. (Association for the Sciences of Limnology and Oceanography, 2021-08-02)
    Effects of climate change-driven disturbance on lake ecosystems can be subtle; indirect effects include increased nutrient loading that could impact ecosystem function. We designed a low-level fertilization experiment to ...
  • Open ocean particle flux variability from surface to seafloor 

    Cael, B. Barry; Bisson, Kelsey; Conte, Maureen H.; Duret, Manon T.; Follett, Christopher L.; Henson, Stephanie A.; Honda, Makio C.; Iversen, Morten H.; Karl, David M.; Lampitt, Richard S.; Mouw, Colleen B.; Muller-Karger, Frank E.; Pebody, Corinne; Smith, Kenneth L., Jr.; Talmy, David (American Geophysical Union, 2021-04-18)
    The sinking of carbon fixed via net primary production (NPP) into the ocean interior is an important part of marine biogeochemical cycles. NPP measurements follow a log-normal probability distribution, meaning NPP variations ...
  • A cross-institutional analysis of the effects of broadening trainee professional development on research productivity 

    Brandt, Patrick D.; Sturzenegger Varvayanis, Susi; Baas, Tracey; Bolgioni, Amanda F.; Alder, Janet; Petrie, Kimberly A.; Dominguez, Isabel; Brown, Abigail M.; Stayart, C. Abigail; Singh, Harinder; Van Wart, Audra; Chow, Christine S.; Mathur, Ambika; Schreiber, Barbara M.; Fruman, David A.; Bowden, Brent; Wiesen, Christopher A.; Golightly, Yvonne M.; Holmquist, Chris E.; Arneman, Daniel; Hall, Joshua D.; Hyman, Linda E.; Gould, Kathleen L.; Chalkley, Roger; Brennwald, Patrick J.; Layton, Rebekah L. (Public Library of Science, 2021-07-15)
    PhD-trained scientists are essential contributors to the workforce in diverse employment sectors that include academia, industry, government, and nonprofit organizations. Hence, best practices for training the future ...
  • Teamwork in the viscous oceanic microscale 

    Kanso, Eva A.; Lopes, Rubens M.; Strickler, J. Rudi; Dabiri, John O.; Costello, John H. (National Academy of Sciences, 2021-07-16)
    Nutrient acquisition is crucial for oceanic microbes, and competitive solutions to solve this challenge have evolved among a range of unicellular protists. However, solitary solutions are not the only approach found in ...
  • Corals regulate the distribution and abundance of Symbiodiniaceae and biomolecules in response to changing water depth and sea surface temperature 

    Sivaguru, Mayandi; Todorov, Lauren G.; Fouke, Courtney E.; Munro, Cara M. O.; Fouke, Kyle W.; Fouke, Kaitlyn E.; Baughman, Melinda E.; Fouke, Bruce W. (Nature Research, 2021-01-26)
    The Scleractinian corals Orbicella annularis and O. faveolata have survived by acclimatizing to environmental changes in water depth and sea surface temperature (SST). However, the complex physiological mechanisms by which ...
  • Intranuclear birefringent inclusions in paraffin sections by polychromatic polarization microscopy 

    Vitkunaite, Aiste; Laurinaviciene, Aida; Plancoulaine, Benoit; Rasmusson, Allan; Levenson, Richard; Shribak, Michael; Laurinavicius, Arvydas (Nature Research, 2021-03-18)
    Intranuclear birefringent inclusions (IBI) found in various cell types in paraffin-embedded tissue sections have long been considered to be a tissue processing artifact, although an association with biological processes ...
  • NLRP3 inflammasome assembly in neutrophils is supported by PAD4 and promotes NETosis under sterile conditions 

    Münzer, Patrick; Negro, Roberto; Fukui, Shoichi; di Meglio, Lucas; Aymonnier, Karen; Chu, Long; Cherpokova, Deya; Gutch, Sarah; Sorvillo, Nicoletta; Shi, Lai; Magupalli, Venkat Giri; Weber, Alexander N. R.; Scharf, Rüdiger E.; Waterman, Clare M.; Wu, Hao; Wagner, Denisa D. (Frontiers Media, 2021-03-28)
    Neutrophil extracellular trap formation (NETosis) and the NLR family pyrin domain containing 3 (NLRP3) inflammasome assembly are associated with a similar spectrum of human disorders. While NETosis is known to be regulated ...
  • Degradation of biological macromolecules supports uncultured microbial populations in Guaymas Basin hydrothermal sediments 

    Pérez Castro, Sherlynette; Borton, Mikayla A.; Regan, Kathleen M.; Hrabe de Angelis, Isabella; Wrighton, Kelly C.; Teske, Andreas P.; Strous, Marc; Ruff, S. Emil (Springer Nature, 2021-06-10)
    Hydrothermal sediments contain large numbers of uncultured heterotrophic microbial lineages. Here, we amended Guaymas Basin sediments with proteins, polysaccharides, nucleic acids or lipids under different redox conditions ...
  • Post-stroke epileptogenesis is associated with altered intrinsic properties of hippocampal pyramidal neurons leading to increased theta resonance 

    Vera, Jorge; Lippmann, Kristina (Elsevier, 2021-06-10)
    Brain insults like stroke, trauma or infections often lead to blood-brain barrier-dysfunction (BBBd) frequently resulting into epileptogenesis. Affected patients suffer from seizures and cognitive comorbidities that are ...
  • Fungal community response to long-term soil warming with potential implications for soil carbon dynamics 

    Pec, Gregory J.; van Diepen, Linda T. A.; Knorr, Melissa; Grandy, A. Stuart; Melillo, Jerry M.; DeAngelis, Kristen M.; Blanchard, Jeffrey L.; Frey, Serita D. (Ecological Society of America, 2021-05-11)
    The direction and magnitude of climate warming effects on ecosystem processes such as carbon cycling remain uncertain. Soil fungi are central to these processes due to their roles as decomposers of soil organic matter, as ...
  • Time lags: insights from the U.S. Long Term Ecological Research Network 

    Rastetter, Edward B.; Ohman, Mark D.; Elliott, Katherine J.; Rehage, Jennifer S.; Rivera-Monroy, Victor H.; Boucek, Ross E.; Castaneda-Moya, Edward; Danielson, Tess M.; Gough, Laura; Groffman, Peter M.; Jackson, C. Rhett; Ford Miniat, Chelcy (Ecological Society of America, 2021-05-17)
    Ecosystems across the United States are changing in complex ways that are difficult to predict. Coordinated long-term research and analysis are required to assess how these changes will affect a diverse array of ecosystem ...
  • Oxygen supply capacity breathes new life into critical oxygen partial pressure (Pcrit) 

    Seibel, Brad A.; Andres, Alyssa; Birk, Matthew A.; Burns, Alexandra L.; Shaw, C. Tracy; Timpe, Alexander W.; Welsh, Christina J. (The Company of Biologists, 2021-04-30)
    The critical oxygen partial pressure (Pcrit), typically defined as the PO2 below which an animal's metabolic rate (MR) is unsustainable, is widely interpreted as a measure of hypoxia tolerance. Here, Pcrit is defined as ...
  • Global ocean sediment composition and burial flux in the deep sea 

    Hayes, Christopher T.; Costa, Kassandra M.; Anderson, Robert F.; Calvo, Eva; Chase, Zanna; Demina, Ludmila L.; Dutay, Jean-Claude; German, Christopher R.; Heimbürger, Lars-Eric; Jaccard, Samuel L.; Jacobel, Allison W.; Kohfeld, Karen E.; Kravchishina, Marina; Lippold, Jörg; Mekik, Figen; Missiaen, Lise; Pavia, Frank; Paytan, Adina; Pedrosa-Pamies, Rut; Petrova, Mariia V.; Rahman, Shaily; Robinson, Laura F.; Roy-Barman, Matthieu; Sanchez-Vidal, Anna; Shiller, Alan M.; Tagliabue, Alessandro; Tessin, Allyson C.; van Hulten, Marco; Zhang, Jing (American Geophysical Union, 2021-03-21)
    Quantitative knowledge about the burial of sedimentary components at the seafloor has wide-ranging implications in ocean science, from global climate to continental weathering. The use of 230Th-normalized fluxes reduces ...
  • Postnatal structural development of mammalian basilar membrane provides anatomical basis for the maturation of tonotopic maps and frequency tuning 

    Tani, Tomomi; Koike-Tani, Maki; Tran, Mai Thi; Shribak, Michael; Levic, Snezana (Nature Research, 2021-04-07)
    The basilar membrane (BM) of the mammalian cochlea constitutes a spiraling acellular ribbon that is intimately attached to the organ of Corti. Its graded stiffness, increasing from apex to the base of the cochlea provides ...

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