Imrie H.

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  • Article
    Light and electron microscopical observations of the effects of high-density lipoprotein on growth of Plasmodium falciparum in vitro
    (Cambridge University Press, 2004-05-13) Imrie, H. ; Ferguson, D. J. P. ; Carter, M. ; Drain, J. ; Schiflett, A. ; Hajduk, Stephen L. ; Day, K. P.
    Human serum high-density lipoprotein (HDL) is necessary and sufficient for the short-term maintenance of Plasmodium falciparum in in vitro culture. However, at high concentrations it is toxic to the parasite. A heat-labile component is apparently responsible for the stage-specific toxicity to parasites within infected erythrocytes 12–42 h after invasion, i.e. during trophozoite maturation. The effects of HDL on parasite metabolism (as determined by nucleic acid synthesis) are evident at about 30 h after invasion. Parasites treated with HDL show gross abnormalities by light and electron microscopy.