Light and electron microscopical observations of the effects of high-density lipoprotein on growth of Plasmodium falciparum in vitro

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Date
2004-05-13
Authors
Imrie, H.
Ferguson, D. J. P.
Carter, M.
Drain, J.
Schiflett, A.
Hajduk, Stephen L.
Day, K. P.
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10.1017/S0031182004005025
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Keywords
Plasmodium falciparum
High density lipoprotein
Abstract
Human serum high-density lipoprotein (HDL) is necessary and sufficient for the short-term maintenance of Plasmodium falciparum in in vitro culture. However, at high concentrations it is toxic to the parasite. A heat-labile component is apparently responsible for the stage-specific toxicity to parasites within infected erythrocytes 12–42 h after invasion, i.e. during trophozoite maturation. The effects of HDL on parasite metabolism (as determined by nucleic acid synthesis) are evident at about 30 h after invasion. Parasites treated with HDL show gross abnormalities by light and electron microscopy.
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Author Posting. © Cambridge University Press, 2004. This article is posted here by permission of Cambridge University Press for personal use, not for redistribution. The definitive version was published in Parasitology 128 (2004): 577-584, doi:10.1017/S0031182004005025.
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Parasitology 128 (2004): 577-584
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