Light and electron microscopical observations of the effects of high-density lipoprotein on growth of Plasmodium falciparum in vitro
Light and electron microscopical observations of the effects of high-density lipoprotein on growth of Plasmodium falciparum in vitro
Date
2004-05-13
Authors
Imrie, H.
Ferguson, D. J. P.
Carter, M.
Drain, J.
Schiflett, A.
Hajduk, Stephen L.
Day, K. P.
Ferguson, D. J. P.
Carter, M.
Drain, J.
Schiflett, A.
Hajduk, Stephen L.
Day, K. P.
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DOI
10.1017/S0031182004005025
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Plasmodium falciparum
High density lipoprotein
High density lipoprotein
Abstract
Human serum high-density lipoprotein (HDL) is necessary and sufficient for the short-term maintenance of Plasmodium falciparum in in vitro culture. However, at high concentrations it is toxic to the parasite. A heat-labile component is apparently responsible for the stage-specific toxicity to parasites within infected erythrocytes 12–42 h after invasion, i.e. during trophozoite maturation. The effects of HDL on parasite metabolism (as determined by nucleic acid synthesis) are evident at about 30 h after invasion. Parasites treated with HDL show gross abnormalities by light and electron microscopy.
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Author Posting. © Cambridge University Press, 2004. This article is posted here by permission of Cambridge University Press for personal use, not for redistribution. The definitive version was published in Parasitology 128 (2004): 577-584, doi:10.1017/S0031182004005025.
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Parasitology 128 (2004): 577-584