Sex as a biological variable in tissue engineering and regenerative medicine
Sex as a biological variable in tissue engineering and regenerative medicine
| dc.contributor.author | Allen, Josephine B. | |
| dc.contributor.author | Ludtka, Christopher | |
| dc.contributor.author | James, Bryan D. | |
| dc.date.accessioned | 2024-02-07T19:24:39Z | |
| dc.date.available | 2024-02-07T19:24:39Z | |
| dc.date.issued | 2023-04-27 | |
| dc.description | © The Author(s), 2023. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Allen, J. B., Ludtka, C., & James, B. D. Sex as a biological variable in tissue engineering and regenerative medicine. Annual Review of Biomedical Engineering, 25, (2023): 311–331, https://doi.org/10.1146/annurev-bioeng-092222-030857. | |
| dc.description.abstract | Although sex differences have been noted in cellular function and behavior, therapy efficacy, and disease incidence and outcomes, the adoption of sex as a biological variable in tissue engineering and regenerative medicine remains limited. Furthering the development of personalized, precision medicine requires considering biological sex at the bench and in the clinic. This review provides the basis for considering biological sex when designing tissue-engineered constructs and regenerative therapies by contextualizing sex as a biological variable within the tissue engineering triad of cells, matrices, and signals. To achieve equity in biological sex within medicine requires a cultural shift in science and engineering research, with active engagement by researchers, clinicians, companies, policymakers, and funding agencies. | |
| dc.description.sponsorship | J.B.A. and C.L. receive support from the National Institutes of Health R01 grant 5R01HL130493. C.L. is supported by the National Institutes of Health T32 grant T32DK10876. B.D.J. is supported by the Postdoctoral Scholar Program at the Woods Hole Oceanographic Institution, with funding provided by the Weston Howland Jr. Postdoctoral Scholarship. | |
| dc.identifier.citation | Allen, J. B., Ludtka, C., & James, B. D. (2023). Sex as a biological variable in tissue engineering and regenerative medicine. Annual Review of Biomedical Engineering, 25, 311–331. | |
| dc.identifier.doi | 10.1146/annurev-bioeng-092222-030857 | |
| dc.identifier.uri | https://hdl.handle.net/1912/67587 | |
| dc.publisher | Annual Reviews | |
| dc.relation.uri | https://doi.org/10.1146/annurev-bioeng-092222-030857 | |
| dc.rights | Attribution 4.0 International | * |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
| dc.subject | Precision medicine | |
| dc.subject | Sexual dimorphism | |
| dc.subject | Sex differences | |
| dc.subject | Tissue models | |
| dc.subject | Stem cells | |
| dc.subject | Sex characteristics | |
| dc.title | Sex as a biological variable in tissue engineering and regenerative medicine | |
| dc.type | Article | |
| dspace.entity.type | Publication | |
| relation.isAuthorOfPublication | f3f55fb0-7ad6-4484-9100-200664c91640 | |
| relation.isAuthorOfPublication.latestForDiscovery | f3f55fb0-7ad6-4484-9100-200664c91640 |
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