Fabian Peter

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Fabian
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Peter
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  • Article
    Gill developmental program in the teleost mandibular arch
    (eLife Sciences Publications, 2022-06-28) Thiruppathy, Mathi ; Fabian, Peter ; Gillis, J. Andrew ; Crump, J. Gage
    Whereas no known living vertebrate possesses gills derived from the jaw-forming mandibular arch, it has been proposed that the jaw arose through modifications of an ancestral mandibular gill. Here, we show that the zebrafish pseudobranch, which regulates blood pressure in the eye, develops from mandibular arch mesenchyme and first pouch epithelia and shares gene expression, enhancer utilization, and developmental gata3 dependence with the gills. Combined with work in chondrichthyans, our findings in a teleost fish point to the presence of a mandibular pseudobranch with serial homology to gills in the last common ancestor of jawed vertebrates, consistent with a gill origin of vertebrate jaws.
  • Article
    A pre-vertebrate endodermal origin of calcitonin-producing neuroendocrine cells
    (The Company of Biologists, 2024-08-07) Rees, Jenaid M. ; Kirk, Katie ; Gattoni, Giacomo ; Hockman, Dorit ; Sleight, Victoria A. ; Ritter, Dylan J. ; Benito-Gutierrez, Elia ; Knapik, Ela W. ; Crump, J. Gage ; Fabian, Peter ; Gillis, J. Andrew
    Vertebrate calcitonin-producing cells (C-cells) are neuroendocrine cells that secrete the small peptide hormone calcitonin in response to elevated blood calcium levels. Whereas mouse C-cells reside within the thyroid gland and derive from pharyngeal endoderm, avian C-cells are located within ultimobranchial glands and have been reported to derive from the neural crest. We use a comparative cell lineage tracing approach in a range of vertebrate model systems to resolve the ancestral embryonic origin of vertebrate C-cells. We find, contrary to previous studies, that chick C-cells derive from pharyngeal endoderm, with neural crest-derived cells instead contributing to connective tissue intimately associated with C-cells in the ultimobranchial gland. This endodermal origin of C-cells is conserved in a ray-finned bony fish (zebrafish) and a cartilaginous fish (the little skate, Leucoraja erinacea). Furthermore, we discover putative C-cell homologs within the endodermally-derived pharyngeal epithelium of the ascidian Ciona intestinalis and the amphioxus Branchiostoma lanceolatum, two invertebrate chordates that lack neural crest cells. Our findings point to a conserved endodermal origin of C-cells across vertebrates and to a pre-vertebrate origin of this cell type along the chordate stem.