Nyholm Spencer V.

No Thumbnail Available
Last Name
Nyholm
First Name
Spencer V.
ORCID

Filters

2012 - 2019 1 2020 - 2022 1
2
2
Reset filters

Settings

Search Results

Now showing 1 - 2 of 2
  • Article
    Cephalopod genomics : a plan of strategies and organization
    (Genomic Standards Consortium, 2012-09-26) Albertin, Caroline B. ; Bonnaud, Laure ; Brown, C. Titus ; Crookes-Goodson, Wendy J. ; da Fonseca, Rute R. ; Di Cristo, Carlo ; Dilkes, Brian P. ; Edsinger-Gonzales, Eric ; Freeman, Robert J. ; Hanlon, Roger T. ; Koenig, Kristen M. ; Lindgren, Annie R. ; Martindale, Mark Q. ; Minx, Patrick ; Moroz, Leonid L. ; Nodl, Marie-Therese ; Nyholm, Spencer V. ; Ogura, Atsushi ; Pungor, Judit R. ; Rosenthal, Joshua J. C. ; Schwarz, Erich M. ; Shigeno, Shuichi ; Strugnell, Jan M. ; Wollesen, Tim ; Zhang, Guojie ; Ragsdale, Clifton W.
    The Cephalopod Sequencing Consortium (CephSeq Consortium) was established at a NESCent Catalysis Group Meeting, “Paths to Cephalopod Genomics- Strategies, Choices, Organization,” held in Durham, North Carolina, USA on May 24-27, 2012. Twenty-eight participants representing nine countries (Austria, Australia, China, Denmark, France, Italy, Japan, Spain and the USA) met to address the pressing need for genome sequencing of cephalopod molluscs. This group, drawn from cephalopod biologists, neuroscientists, developmental and evolutionary biologists, materials scientists, bioinformaticians and researchers active in sequencing, assembling and annotating genomes, agreed on a set of cephalopod species of particular importance for initial sequencing and developed strategies and an organization (CephSeq Consortium) to promote this sequencing. The conclusions and recommendations of this meeting are described in this White Paper.
  • Article
    Emergence of novel cephalopod gene regulation and expression through large-scale genome reorganization
    (Nature Research, 2022-04-21) Schmidbaur, Hannah ; Kawaguchi, Akane ; Clarence, Tereza ; Fu, Xiao ; Hoang, Oi Pui ; Zimmermann, Bob ; Ritschard, Elena A. ; Weissenbacher, Anton ; Foster, Jamie S. ; Nyholm, Spencer V. ; Bates, Paul A. ; Albertin, Carolin B. ; Tanaka, Elly ; Simakov, Oleg
    Coleoid cephalopods (squid, cuttlefish, octopus) have the largest nervous system among invertebrates that together with many lineage-specific morphological traits enables complex behaviors. The genomic basis underlying these innovations remains unknown. Using comparative and functional genomics in the model squid Euprymna scolopes, we reveal the unique genomic, topological, and regulatory organization of cephalopod genomes. We show that coleoid cephalopod genomes have been extensively restructured compared to other animals, leading to the emergence of hundreds of tightly linked and evolutionary unique gene clusters (microsyntenies). Such novel microsyntenies correspond to topological compartments with a distinct regulatory structure and contribute to complex expression patterns. In particular, we identify a set of microsyntenies associated with cephalopod innovations (MACIs) broadly enriched in cephalopod nervous system expression. We posit that the emergence of MACIs was instrumental to cephalopod nervous system evolution and propose that microsyntenic profiling will be central to understanding cephalopod innovations.