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dc.contributor.authorGiovannelli, Donato  Concept link
dc.contributor.authorSievert, Stefan M.  Concept link
dc.contributor.authorHugler, Michael  Concept link
dc.contributor.authorMarkert, Stephanie  Concept link
dc.contributor.authorBecher, Dorte  Concept link
dc.contributor.authorSchweder, Thomas  Concept link
dc.contributor.authorVetriani, Costantino  Concept link
dc.date.accessioned2017-06-14T15:31:04Z
dc.date.available2017-06-14T15:31:04Z
dc.date.issued2017-04-24
dc.identifier.citationeLife 6 (2017): e18990en_US
dc.identifier.urihttps://hdl.handle.net/1912/9045
dc.description© The Author(s), 2017. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in eLife 6 (2017): e18990, doi:10.7554/eLife.18990.en_US
dc.description.abstractAnaerobic thermophiles inhabit relic environments that resemble the early Earth. However, the lineage of these modern organisms co-evolved with our planet. Hence, these organisms carry both ancestral and acquired genes and serve as models to reconstruct early metabolism. Based on comparative genomic and proteomic analyses, we identified two distinct groups of genes in Thermovibrio ammonificans: the first codes for enzymes that do not require oxygen and use substrates of geothermal origin; the second appears to be a more recent acquisition, and may reflect adaptations to cope with the rise of oxygen on Earth. We propose that the ancestor of the Aquificae was originally a hydrogen oxidizing, sulfur reducing bacterium that used a hybrid pathway for CO2 fixation. With the gradual rise of oxygen in the atmosphere, more efficient terminal electron acceptors became available and this lineage acquired genes that increased its metabolic flexibility while retaining ancestral metabolic traits.en_US
dc.description.sponsorshipNational Science Foundation (MCB 04-56676), (OCE 03-27353), (MCB 08-43678), (OCE 09-37371), (OCE 11-24141), (MCB 15-17567), (OCE-1136727); National Aeronautics and Space Administration (NNX15AM18G);en_US
dc.language.isoen_USen_US
dc.publishereLifeen_US
dc.relation.urihttps://doi.org/10.7554/eLife.18990
dc.rightsAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.titleInsight into the evolution of microbial metabolism from the deep-branching bacterium, Thermovibrio ammonificansen_US
dc.typeArticleen_US
dc.identifier.doi10.7554/eLife.18990


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Attribution 4.0 International
Except where otherwise noted, this item's license is described as Attribution 4.0 International