Thyroid and adrenal factors in hyaline membrane disease
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https://hdl.handle.net/1912/4625Abstract
Pulmonary fibrosis implies antecedent lung injury which may or may not include inflammatory
responses of the ordinary sort. The onset of breathing at mammalian birth is a different kind of lung
injury, one occasioned by great physical stretch of the collapsed but moist fetal lung, and immediate
exposure to over ten times the level of oxygen resident in the fetal organ. Access to a large archive,
the perinatal mortality review from the Chicago Lying-In Hospital, has provided information very
relevant to these questions, including the first regular documentation of the pulmonary lesion
complex as related to clinical care: beginning in the late 1930s. The lesion complex is called hyaline
membrane disease (HMD) from the condensation at the tissue:gas interface of protein exuded from
the lung and its circulation.
Description
Author Posting. © The Author(s), 2011. Presented at Advances in inflammatory and fibrosing lung diseases. Sunday, April 10,
2011, Experimental Biology 2011, Washington, D.C.