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Characterisation of the subtelomeric regions of Giardia lamblia genome isolate WBC6

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dc.contributor.author Prabhu, Anjali
dc.contributor.author Morrison, Hilary G.
dc.contributor.author Martinez, Charles R.
dc.contributor.author Adam, Rodney D.
dc.date.accessioned 2007-06-06T17:35:11Z
dc.date.available 2007-06-06T17:35:11Z
dc.date.issued 2006-12-04
dc.identifier.uri http://hdl.handle.net/1912/1698
dc.description Author Posting. © The Author(s), 2007. This is the author's version of the work. It is posted here by permission of Elsevier B.V. for personal use, not for redistribution. The definitive version was published in International Journal for Parasitology 37 (2007): 503-513, doi:10.1016/j.ijpara.2006.12.011. en
dc.description.abstract Giardia trophozoites are polyploid and have five chromosomes. The chromosome homologues demonstrate considerable size heterogeneity due to variation in the subtelomeric regions. We used clones from the genome project with telomeric sequence at one end to identify six subtelomeric regions in addition to previously identified subtelomeric regions, to study the telomeric arrangement of the chromosomes. The subtelomeric regions included two retroposons, one retroposon pseudogene, and two vsp genes, in addition to the previously identified subtelomeric regions that include ribosomal DNA repeats. The presence of vsp genes in a subtelomeric region suggests that telomeric rearrangements may contribute to the generation of vsp diversity. These studies of the subtelomeric regions of Giardia may contribute to our understanding of the factors that maintain stability, while allowing diversity in chromosome structure. en
dc.description.sponsorship This work was supported in part by NIH grant AI43273 to Mitchell L. Sogin. Additional support was provided by the G. Unger Vetlesen Foundation and LI-COR Biotechnology. en
dc.format.mimetype application/pdf
dc.language.iso en_US en
dc.relation.uri http://dx.doi.org/10.1016/j.ijpara.2006.12.011
dc.subject Giardia lamblia en
dc.subject Telomere en
dc.subject Subtelomeric region en
dc.subject vsp en
dc.subject Retroposon en
dc.title Characterisation of the subtelomeric regions of Giardia lamblia genome isolate WBC6 en
dc.type Preprint en


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