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dc.contributor.authorPrabhu, Anjali
dc.contributor.authorMorrison, Hilary G.
dc.contributor.authorMartinez, Charles R.
dc.contributor.authorAdam, Rodney D.
dc.date.accessioned2007-06-06T17:35:11Z
dc.date.available2007-06-06T17:35:11Z
dc.date.issued2006-12-04
dc.identifier.urihttp://hdl.handle.net/1912/1698
dc.descriptionAuthor Posting. © The Author(s), 2007. This is the author's version of the work. It is posted here by permission of Elsevier B.V. for personal use, not for redistribution. The definitive version was published in International Journal for Parasitology 37 (2007): 503-513, doi:10.1016/j.ijpara.2006.12.011.en
dc.description.abstractGiardia trophozoites are polyploid and have five chromosomes. The chromosome homologues demonstrate considerable size heterogeneity due to variation in the subtelomeric regions. We used clones from the genome project with telomeric sequence at one end to identify six subtelomeric regions in addition to previously identified subtelomeric regions, to study the telomeric arrangement of the chromosomes. The subtelomeric regions included two retroposons, one retroposon pseudogene, and two vsp genes, in addition to the previously identified subtelomeric regions that include ribosomal DNA repeats. The presence of vsp genes in a subtelomeric region suggests that telomeric rearrangements may contribute to the generation of vsp diversity. These studies of the subtelomeric regions of Giardia may contribute to our understanding of the factors that maintain stability, while allowing diversity in chromosome structure.en
dc.description.sponsorshipThis work was supported in part by NIH grant AI43273 to Mitchell L. Sogin. Additional support was provided by the G. Unger Vetlesen Foundation and LI-COR Biotechnology.en
dc.format.mimetypeapplication/pdf
dc.language.isoen_USen
dc.relation.urihttps://doi.org/10.1016/j.ijpara.2006.12.011
dc.subjectGiardia lambliaen
dc.subjectTelomereen
dc.subjectSubtelomeric regionen
dc.subjectvspen
dc.subjectRetroposonen
dc.titleCharacterisation of the subtelomeric regions of Giardia lamblia genome isolate WBC6en
dc.typePreprinten


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