Gene duplications and evolution of vertebrate voltage-gated sodium channels

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2006-03-01Author
Novak, Alicia E.
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Jost, Manda C.
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Lu, Ying
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Taylor, Alison D.
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Zakon, Harold H.
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Ribera, Angeles B.
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https://hdl.handle.net/1912/1203As published
https://doi.org/10.1007/s00239-005-0287-9Abstract
Voltage-gated sodium channels underlie action potential generation in excitable tissue.
To establish the evolutionary mechanisms that shaped the vertebrate sodium channel
a-subunit (SCNA) gene family and their encoded Nav1 proteins, we identified all SCNA
genes in several teleost species. Molecular cloning revealed that teleosts have eight
SCNA genes, comparable to the number in another vertebrate lineage, mammals.
Prior phylogenetic analyses had indicated that teleosts and tetrapods share four
monophyletic groups of SCNA genes and that tandem duplications selectively
expanded the number of genes in two of the four mammalian groups. However, the
number of genes in each group varies between teleosts and tetrapods suggesting
different evolutionary histories in the two vertebrate lineages. Our findings from
phylogenetic analysis and chromosomal mapping of Danio rerio genes indicate that
tandem duplications are an unlikely mechanism for generation of the extant teleost
SCNA genes. Instead, analysis of other closely mapped genes in D. rerio supports the
hypothesis that a whole genome duplication was involved in expansion of the SCNA
gene family in teleosts. Interestingly, despite their different evolutionary histories,
mRNA analyses demonstrated a conservation of expression patterns for SCNA
orthologues in teleosts and tetrapods, suggesting functional conservation.
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Author Posting. © The Author(s), 2006. This is the author's version of the work. It is posted here by permission of Springer for personal use, not for redistribution. The definitive version was published in Journal of Molecular Evolution 63 (2006): 208-221, doi:10.1007/s00239-005-0287-9.
Suggested Citation
Preprint: Novak, Alicia E., Jost, Manda C., Lu, Ying, Taylor, Alison D., Zakon, Harold H., Ribera, Angeles B., "Gene duplications and evolution of vertebrate voltage-gated sodium channels", 2006-03-01, https://doi.org/10.1007/s00239-005-0287-9, https://hdl.handle.net/1912/1203Related items
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