• Login
    About WHOAS
    View Item 
    •   WHOAS Home
    • Marine Biological Laboratory
    • Josephine Bay Paul Center in Comparative Molecular Biology and Evolution
    • View Item
    •   WHOAS Home
    • Marine Biological Laboratory
    • Josephine Bay Paul Center in Comparative Molecular Biology and Evolution
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of WHOASCommunities & CollectionsBy Issue DateAuthorsTitlesKeywordsThis CollectionBy Issue DateAuthorsTitlesKeywords

    My Account

    LoginRegister

    Statistics

    View Usage Statistics

    Gene duplications and evolution of vertebrate voltage-gated sodium channels

    Thumbnail
    View/Open
    Novak et al-JME-00287.pdf (4.663Mb)
    Date
    2006-03-01
    Author
    Novak, Alicia E.  Concept link
    Jost, Manda C.  Concept link
    Lu, Ying  Concept link
    Taylor, Alison D.  Concept link
    Zakon, Harold H.  Concept link
    Ribera, Angeles B.  Concept link
    Metadata
    Show full item record
    Citable URI
    https://hdl.handle.net/1912/1203
    As published
    https://doi.org/10.1007/s00239-005-0287-9
    Keyword
     Voltage-gated sodium channel; Teleosts; Gene families; Genome duplication; Gene duplication 
    Abstract
    Voltage-gated sodium channels underlie action potential generation in excitable tissue. To establish the evolutionary mechanisms that shaped the vertebrate sodium channel a-subunit (SCNA) gene family and their encoded Nav1 proteins, we identified all SCNA genes in several teleost species. Molecular cloning revealed that teleosts have eight SCNA genes, comparable to the number in another vertebrate lineage, mammals. Prior phylogenetic analyses had indicated that teleosts and tetrapods share four monophyletic groups of SCNA genes and that tandem duplications selectively expanded the number of genes in two of the four mammalian groups. However, the number of genes in each group varies between teleosts and tetrapods suggesting different evolutionary histories in the two vertebrate lineages. Our findings from phylogenetic analysis and chromosomal mapping of Danio rerio genes indicate that tandem duplications are an unlikely mechanism for generation of the extant teleost SCNA genes. Instead, analysis of other closely mapped genes in D. rerio supports the hypothesis that a whole genome duplication was involved in expansion of the SCNA gene family in teleosts. Interestingly, despite their different evolutionary histories, mRNA analyses demonstrated a conservation of expression patterns for SCNA orthologues in teleosts and tetrapods, suggesting functional conservation.
    Description
    Author Posting. © The Author(s), 2006. This is the author's version of the work. It is posted here by permission of Springer for personal use, not for redistribution. The definitive version was published in Journal of Molecular Evolution 63 (2006): 208-221, doi:10.1007/s00239-005-0287-9.
    Collections
    • Josephine Bay Paul Center in Comparative Molecular Biology and Evolution
    Suggested Citation
    Preprint: Novak, Alicia E., Jost, Manda C., Lu, Ying, Taylor, Alison D., Zakon, Harold H., Ribera, Angeles B., "Gene duplications and evolution of vertebrate voltage-gated sodium channels", 2006-03-01, https://doi.org/10.1007/s00239-005-0287-9, https://hdl.handle.net/1912/1203
     

    Related items

    Showing items related by title, author, creator and subject.

    • Thumbnail

      Adaptive evolution of voltage-gated sodium channels : the first 800 million years 

      Zakon, Harold H. (2012-04)
      Voltage-gated Na+-permeable (Nav) channels form the basis for electrical excitability in animals. Nav channels evolved from Ca2+ channels and were present in the common ancestor of choanoflagellates and animals although ...
    • Thumbnail

      Voltage-gated calcium channel subunits from platyhelminths : potential role in praziquantel action 

      Jeziorski, Michael C.; Greenberg, Robert M. (2006-02-07)
      Voltage-gated calcium (Ca2+) channels provide the pathway for Ca2+ influxes that underlie Ca2+-dependent responses in muscles, nerves, and other excitable cells. They are also targets of a wide variety of drugs and toxins. ...
    • Thumbnail

      Ca2+ signalling, voltage-gated Ca2+ channels and praziquantel in flatworm neuromusculature 

      Greenberg, Robert M. (2005-10)
      Transient changes in calcium (Ca2+) levels regulate a wide variety of cellular processes, and cells employ both intracellular and extracellular sources of Ca2+ for signaling. Praziquantel, the drug of choice against ...
    All Items in WHOAS are protected by original copyright, with all rights reserved, unless otherwise indicated. WHOAS also supports the use of the Creative Commons licenses for original content.
    A service of the MBLWHOI Library | About WHOAS
    Contact Us | Send Feedback | Privacy Policy
    Core Trust Logo