Hsc70 rescues the synaptic vesicle trafficking defects caused by α-synuclein dimers
Hsc70 rescues the synaptic vesicle trafficking defects caused by α-synuclein dimers
Date
2023-03-01
Authors
Brady, Emily B
McQuillan, Molly
Medeiros, Audrey T
Bubacco, Luigi
Sousa, Rui
Lafer, Eileen M
Morgan, Jennifer R
McQuillan, Molly
Medeiros, Audrey T
Bubacco, Luigi
Sousa, Rui
Lafer, Eileen M
Morgan, Jennifer R
Linked Authors
Person
Person
Person
Person
Person
Alternative Title
Citable URI
As Published
Date Created
Location
DOI
10.17912/micropub.biology.000737
Related Materials
Replaces
Replaced By
Keywords
Abstract
Aberrant buildup of α-synuclein is associated with Parkinson's disease (PD) and other neurodegenerative disorders. At synapses, α-synuclein accumulation leads to severe synaptic vesicle trafficking defects. We previously demonstrated that different molecular species of α-synuclein produce distinct effects on synaptic vesicle recycling, and that the synaptic phenotypes caused by monomeric α-synuclein were ameliorated by Hsc70. Here, we tested whether Hsc70 could also correct synaptic deficits induced by α-synuclein dimers. Indeed, co-injection of Hsc70 with α-synuclein dimers completely reversed the synaptic deficits, resulting in synapses with normal appearance. This work lends additional support for pursuing chaperone-based strategies to treat PD and other synucleinopathies.
Description
© The Author(s), 2023. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Brady, E., McQuillan, M., Medeiros, A., Bubacco, L., Sousa, R., Lafer, E., & Morgan, J. (2023). Hsc70 rescues the synaptic vesicle trafficking defects caused by α-synuclein dimers. MicroPublication Biology, https://doi.org/10.17912/micropub.biology.000737.
Embargo Date
Citation
Brady, E., McQuillan, M., Medeiros, A., Bubacco, L., Sousa, R., Lafer, E., & Morgan, J. (2023). Hsc70 rescues the synaptic vesicle trafficking defects caused by α-synuclein dimers. MicroPublication Biology.