Histidine suppresses zinc modulation of connexin hemichannels
Histidine suppresses zinc modulation of connexin hemichannels
Date
2004-12
Authors
Chappell, Richard L.
Qian, Haohua
Zakevicius, Jane
Ripps, Harris
Qian, Haohua
Zakevicius, Jane
Ripps, Harris
Linked Authors
Files
Alternative Title
Citable URI
As Published
Date Created
Location
DOI
10.2307/1543206
Related Materials
Replaces
Replaced By
Keywords
Abstract
Zinc has been shown to modulate hemichannel currents of connexins Cx35 and Cx38 in Xenopus oocytes. In both cases the effects were biphasic; i.e., low concentrations of zinc enhanced, whereas higher concentrations decreased, the magnitudes of the voltage-activated hemichannel currents. The present study was designed to determine the effects of zinc on hemichannels formed by Cx26, a connexin reportedly expressed on dendrites of carp horizontal cells and implicated in a mechanism for photoreceptor feedback. In addition, we examined whether histidine, a zinc chelator, would block the action of zinc on Cx26 hemichannel currents, or would exert a direct effect on those currents.
Description
Author Posting. © Marine Biological Laboratory, 2004. This article is posted here by permission of Marine Biological Laboratory for personal use, not for redistribution. The definitive version was published in Biological Bulletin 207 (2004): 188-190.
Embargo Date
Citation
Biological Bulletin 207 (2004): 188-190