Xenopus as a model for GI/pancreas disease

dc.contributor.author Salanga, Matthew C.
dc.contributor.author Horb, Marko E.
dc.date.accessioned 2015-08-18T13:46:37Z
dc.date.available 2016-04-02T08:57:45Z
dc.date.issued 2015-03
dc.description Author Posting. © The Author(s), 2015. This is the author's version of the work. It is posted here by permission of Springer for personal use, not for redistribution. The definitive version was published in Current Pathobiology Reports 3 (2015): 137-145, doi:10.1007/s40139-015-0076-0. en_US
dc.description.abstract Diseases affecting endodermal organs like the pancreas, lung and gastrointestinal (GI) tract have a substantial impact on human welfare. Since many of these are congenital defects that arise as a result of defects during development broad efforts are focused on understanding the development of these organs so as to better identify risk factors, disease mechanisms and therapeutic targets. Studies implementing model systems, like the amphibian Xenopus, have contributed immensely to our understanding of signaling (e.g. Wnt, FGF, BMP, RA) pathways and gene regulation (e.g. hhex, ptf1a, ngn3) that underlie normal development as well as disease progression. Recent advances in genome engineering further enhance the capabilities of the Xenopus model system for pursuing biomedical research, and will undoubtedly result in a boom of new information underlying disease mechanisms ultimately leading to advancements in diagnosis and therapy. en_US
dc.description.embargo 2016-04-02 en_US
dc.format.mimetype application/pdf
dc.identifier.uri https://hdl.handle.net/1912/7462
dc.language.iso en_US en_US
dc.relation.uri https://doi.org/10.1007/s40139-015-0076-0
dc.subject Xenopus en_US
dc.subject Endoderm en_US
dc.subject Lung en_US
dc.subject GI tract en_US
dc.subject Diabetes en_US
dc.subject Oocyte en_US
dc.subject Pancreas en_US
dc.title Xenopus as a model for GI/pancreas disease en_US
dc.type Preprint en_US
dspace.entity.type Publication
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relation.isAuthorOfPublication.latestForDiscovery 57eb1f3f-0335-476f-8ca0-54cacfa2adcf
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