The African coelacanth genome provides insights into tetrapod evolution

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Amemiya, Chris T.
Alfoldi, Jessica
Lee, Alison P.
Fan, Shaohua
Philippe, Herve
MacCallum, Iain
Braasch, Ingo
Manousaki, Tereza
Schneider, Igor
Rohner, Nicolas
Organ, Chris
Chalopin, Domitille
Smith, Jeramiah J.
Robinson, Mark
Dorrington, Rosemary A.
Gerdol, Marco
Aken, Bronwen
Assunta Biscotti, Maria
Barucca, Marco
Baurain, Denis
Berlin, Aaron M.
Blatch, Gregory L.
Buonocore, Francesco
Burmester, Thorsten
Campbell, Michael S.
Canapa, Adriana
Cannon, John P.
Christoffels, Alan
De Moro, Gianluca
Edkins, Adrienne L.
Fan, Lin
Fausto, Anna Maria
Feiner, Nathalie
Forconi, Mariko
Gamieldien, Junaid
Gnerre, Sante
Gnirke, Andreas
Goldstone, Jared V.
Haerty, Wilfried
Hahn, Mark E.
Hesse, Uljana
Hoffmann, Steve
Johnson, Jeremy
Karchner, Sibel I.
Kuraku, Shigehiro
Lara, Marcia
Levin, Joshua Z.
Litman, Gary W.
Mauceli, Evan
Miyake, Tsutomu
Mueller, M. Gail
Nelson, David R.
Nitsche, Anne
Olmo, Ettore
Ota, Tatsuya
Pallavicini, Alberto
Panji, Sumir
Picone, Barbara
Ponting, Chris P.
Prohaska, Sonja J.
Przybylski, Dariusz
Ratan Saha, Nil
Ravi, Vydianathan
Ribeiro, Filipe J.
Sauka-Spengler, Tatjana
Scapigliati, Giuseppe
Searle, Stephen M. J.
Sharpe, Ted
Simakov, Oleg
Stadler, Peter F.
Stegeman, John J.
Sumiyama, Kenta
Tabbaa, Diana
Tafer, Hakim
Turner-Maier, Jason
van Heusden, Peter
White, Simon
Williams, Louise
Yandell, Mark
Brinkmann, Henner
Volff, Jean-Nicolas
Tabin, Clifford J.
Shubin, Neil
Schartl, Manfred
Jaffe, David B.
Postlethwait, John H.
Venkatesh, Byrappa
Di Palma, Federica
Lander, Eric S.
Meyer, Axel
Lindblad-Toh, Kerstin
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Genome evolution
Comparative genomics
The discovery of a living coelacanth specimen in 1938 was remarkable, as this lineage of lobe-finned fish was thought to have become extinct 70 million years ago. The modern coelacanth looks remarkably similar to many of its ancient relatives, and its evolutionary proximity to our own fish ancestors provides a glimpse of the fish that first walked on land. Here we report the genome sequence of the African coelacanth, Latimeria chalumnae. Through a phylogenomic analysis, we conclude that the lungfish, and not the coelacanth, is the closest living relative of tetrapods. Coelacanth protein-coding genes are significantly more slowly evolving than those of tetrapods, unlike other genomic features. Analyses of changes in genes and regulatory elements during the vertebrate adaptation to land highlight genes involved in immunity, nitrogen excretion and the development of fins, tail, ear, eye, brain and olfaction. Functional assays of enhancers involved in the fin-to-limb transition and in the emergence of extra-embryonic tissues show the importance of the coelacanth genome as a blueprint for understanding tetrapod evolution.
© The Author(s), 2013. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Nature 496 (2013): 311-316, doi:10.1038/nature12027.
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Nature 496 (2013): 311-316
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