Explaining regeneration: cells and limbs as complex living systems, learning from history

dc.contributor.author MacCord, Kate
dc.contributor.author Maienschein, Jane
dc.date.accessioned 2021-11-23T17:32:49Z
dc.date.available 2021-11-23T17:32:49Z
dc.date.issued 2021-08-31
dc.description © The Author(s), 2021. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in MacCord, K., & Maienschein, J. Explaining regeneration: cells and limbs as complex living systems, learning from history. Frontiers in Cell and Developmental Biology, 9, (2021): 734315, https://doi.org/10.3389/fcell.2021.734315. en_US
dc.description.abstract Regeneration has been investigated since Aristotle, giving rise to many ways of explaining what this process is and how it works. Current research focuses on gene expression and cell signaling of regeneration within individual model organisms. We tend to look to model organisms on the reasoning that because of evolution, information gained from other species must in some respect be generalizable. However, for all that we have uncovered about how regeneration works within individual organisms, we have yet to translate what we have gleaned into achieving the goal of regenerative medicine: to harness and enhance our own regenerative abilities. Turning to history may provide a crucial perspective in advancing us toward this goal. History gives perspective, allowing us to reflect on how our predecessors did their work and what assumptions they made, thus also revealing limitations. History, then, may show us how we can move from our current reductionist thinking focused on particular selected model organisms toward generalizations about this crucial process that operates across complex living systems and move closer to repairing our own damaged bodies. en_US
dc.description.sponsorship This article was a product of the McDonnell Initiative at the Marine Biological Laboratory. The McDonnell Initiative began with support from two generous grants from the James S. McDonnell Foundation, along with substantive input from the Foundation Director, Susan Fitzpatrick (“Integrating the Life Sciences with the History and Philosophy of Science” JSMF Grant No. 220020480 and “Transforming Discovery: Historians, Philosophers, and Life Scientists Exploring Regeneration” JSMF Grant No. 220020480.01). en_US
dc.identifier.citation MacCord, K., & Maienschein, J. (2021). Explaining regeneration: cells and limbs as complex living systems, learning from history. Frontiers in Cell and Developmental Biology, 9, 734315. en_US
dc.identifier.doi 10.3389/fcell.2021.734315
dc.identifier.uri https://hdl.handle.net/1912/27776
dc.publisher Frontiers Media en_US
dc.relation.uri https://doi.org/10.3389/fcell.2021.734315
dc.rights Attribution 4.0 International *
dc.rights.uri http://creativecommons.org/licenses/by/4.0/ *
dc.subject regeneration en_US
dc.subject complex living systems en_US
dc.subject Morgan en_US
dc.subject generalizability en_US
dc.subject reductionism en_US
dc.subject model organisms en_US
dc.subject blastema en_US
dc.title Explaining regeneration: cells and limbs as complex living systems, learning from history en_US
dc.type Article en_US
dspace.entity.type Publication
relation.isAuthorOfPublication 12601fb1-4e13-44b1-b2c1-f5f194768207
relation.isAuthorOfPublication 6ac32800-69a5-4584-b14d-01e2c95b73da
relation.isAuthorOfPublication.latestForDiscovery 12601fb1-4e13-44b1-b2c1-f5f194768207
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