Genome sequence of the metazoan plant-parasitic nematode Meloidogyne incognita

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Abad, Pierre
Gouzy, Jerome
Aury, Jean-Marc
Castagnone-Sereno, Philippe
Danchin, Etienne G. J.
Deleury, Emeline
Perfus-Barbeoch, Laetitia
Anthouard, Veronique
Artiguenave, Francois
Blok, Vivian C.
Caillaud, Marie-Cecile
Coutinho, Pedro M.
Da Silva, Corinne
De Luca, Francesca
Deau, Florence
Esquibet, Magali
Flutre, Timothe
Goldstone, Jared V.
Hamamouch, Noureddine
Hewezi, Tarek
Jaillon, Olivier
Jubin, Claire
Leonetti, Paola
Magliano, Marc
Maier, Tom R.
Markov, Gabriel V.
McVeigh, Paul
Pesole, Graziano
Poulain, Julie
Robinson-Rechavi, Marc
Sallet, Erika
Segurens, Beatrice
Steinbach, Delphine
Tytgat, Tom
Ugarte, Edgardo
van Ghelder, Cyril
Veronico, Pasqua
Baum, Thomas J.
Blaxter, Mark
Bleve-Zacheo, Teresa
Davis, Eric L
Ewbank, Jonathan J.
Favery, Bruno
Grenier, Eric
Henrissat, Bernard
Jones, John T.
Laudet, Vincent
Maule, Aaron G.
Quesneville, Hadi
Rosso, Marie-Noelle
Schiex, Thomas
Smant, Geert
Weissenbach, Jean
Wincker, Patrick
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Plant-parasitic nematodes are major agricultural pests worldwide and novel approaches to control them are sorely needed. We report the draft genome sequence of the root-knot nematode Meloidogyne incognita, a biotrophic parasite of many crops, including tomato, cotton and coffee. Most of the assembled sequence of this asexually reproducing nematode, totaling 86 Mb, exists in pairs of homologous but divergent segments. This suggests that ancient allelic regions in M. incognita are evolving toward effective haploidy, permitting new mechanisms of adaptation. The number and diversity of plant cell wall–degrading enzymes in M. incognita is unprecedented in any animal for which a genome sequence is available, and may derive from multiple horizontal gene transfers from bacterial sources. Our results provide insights into the adaptations required by metazoans to successfully parasitize immunocompetent plants, and open the way for discovering new antiparasitic strategies.
© 2008 Nature Publishing Group. This article is distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike license. The definitive version was published in Nature Biotechnology 26 (2008): 909-915, doi:10.1038/nbt.1482.
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Nature Biotechnology 26 (2008): 909-915
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