dc.contributor.author	Celander, Malin C.
dc.contributor.author	Goldstone, Jared V.
dc.contributor.author	Brun, Nadja R.
dc.contributor.author	Clark, Bryan W.
dc.contributor.author	Jayaraman, Saro
dc.contributor.author	Nacci, Diane E.
dc.contributor.author	Stegeman, John J.
dc.date.accessioned	2021-03-17T16:22:19Z
dc.date.available	2021-03-17T16:22:19Z
dc.date.issued	2021-01-08
dc.description	© The Author(s), 2021. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Celander, M. C., Goldstone, J. V., Brun, N. R., Clark, B., Jayaraman, S., Nacci, D., & Stegeman, J. J. Resistance to Cyp3a induction by polychlorinated biphenyls, including non-dioxin-like PCB153, in gills of killifish (Fundulus heteroclitus) from New Bedford Harbor. Environmental Toxicology and Pharmacology, 83, (2021): 103580. doi: 10.1016/j.etap.2020.103580.	en_US
dc.description.abstract	Previous reports suggested that non-dioxin-like (NDL) PCB153 effects on cytochrome P450 3A (Cyp3a) expression in Atlantic killifish (Fundulus heteroclitus) gills differed between F0 generation fish from a PCB site (New Bedford Harbor; NBH) and a reference site (Scorton Creek; SC). Here, we examined effects of PCB153, dioxin-like (DL) PCB126, or a mixture of both, on Cyp3a56 mRNA in killifish generations removed from the wild, without environmental PCB exposures. PCB126 effects in liver and gills differed between populations, as expected. Gill Cyp3a56 was not affected by either congener in NBH F2 generation fish, but was induced by PCB153 in SC F1 fish, with females showing a greater response. PCB153 did not affect Cyp3a56 in liver of either population. Results suggest a heritable resistance to NDL-PCBs in killifish from NBH, in addition to that reported for DL PCBs. Induction of Cyp3a56 in gills may be a biomarker of exposure to NDL PCBs in fish populations that are not resistant to PCBs.	en_US
dc.description.sponsorship	This study was supported by the sabbatical program from the Faculty of Science at the University of Gothenburg (MC), and by the Swiss National Science Foundation P2EZP2-165200 (NRB). The study was supported in part by the Superfund Hazardous Substances Research Program at Boston University NIH P42ES007381 (JVG, JJS). This research was also funded partly by the US Environmental Protection Agency (SJ, DN), including an appointment (BC) with the Postdoctoral Research Program at the US Environmental Protection (US-EPA) Office of Research and Development administered by the Oak Ridge Institute for Science and Education (ORISE), through Interagency Agreement No. DW92429801 between the US Department of Energy and the US-EPA. The contents do not reflect the views of the US-EPA, nor does mention of trade names or commercial products constitute endorsement or recommendation for use by the US-EPA. We thank Rene Francolini at the Woods Hole Oceanographic Institutions for excellent technical assistance and Dr. Sibel Karchner and Dr. Mark Hahn at the Woods Hole Oceanographic Institutions for valuable discussions and comments on the manuscript.	en_US
dc.identifier.citation	Celander, M. C., Goldstone, J. V., Brun, N. R., Clark, B., Jayaraman, S., Nacci, D., & Stegeman, J. J. (2021). Resistance to Cyp3a induction by polychlorinated biphenyls, including non-dioxin-like PCB153, in gills of killifish (Fundulus heteroclitus) from New Bedford Harbor. Environmental Toxicology and Pharmacology, 83, 103580.	en_US
dc.identifier.doi	10.1016/j.etap.2020.103580
dc.identifier.uri	https://hdl.handle.net/1912/26823
dc.publisher	Elsevier	en_US
dc.relation.uri	https://doi.org/10.1016/j.etap.2020.103580
dc.rights	Attribution 4.0 International	*
dc.rights.uri	http://creativecommons.org/licenses/by/4.0/	*
dc.subject	PCB153	en_US
dc.subject	Fish	en_US
dc.subject	Gills	en_US
dc.subject	Cyp3a	en_US
dc.subject	Resistance	en_US
dc.title	Resistance to Cyp3a induction by polychlorinated biphenyls, including non-dioxin-like PCB153, in gills of killifish (Fundulus heteroclitus) from New Bedford Harbor	en_US
dc.type	Article	en_US
dspace.entity.type	Publication
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Resistance to Cyp3a induction by polychlorinated biphenyls, including non-dioxin-like PCB153, in gills of killifish (Fundulus heteroclitus) from New Bedford Harbor

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