Adaptive proteome diversification by nonsynonymous A-to-I RNA editing in coleoid cephalopods

dc.contributor.author Shoshan, Yoav
dc.contributor.author Liscovitch-Brauer, Noa
dc.contributor.author Rosenthal, Joshua J. C.
dc.contributor.author Eisenberg, Eli
dc.date.accessioned 2022-02-25T21:03:45Z
dc.date.available 2022-02-25T21:03:45Z
dc.date.issued 2021-05-22
dc.description © The Author(s), 2021. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Shoshan, Y., Liscovitch-Brauer, N., Rosenthal, J. J. C., & Eisenberg, E. Adaptive proteome diversification by nonsynonymous A-to-I RNA editing in coleoid cephalopods. Molecular Biology and Evolution, 38(9), (2021): 3775–3788, https://doi.org/10.1093/molbev/msab154. en_US
dc.description.abstract RNA editing by the ADAR enzymes converts selected adenosines into inosines, biological mimics for guanosines. By doing so, it alters protein-coding sequences, resulting in novel protein products that diversify the proteome beyond its genomic blueprint. Recoding is exceptionally abundant in the neural tissues of coleoid cephalopods (octopuses, squids, and cuttlefishes), with an over-representation of nonsynonymous edits suggesting positive selection. However, the extent to which proteome diversification by recoding provides an adaptive advantage is not known. It was recently suggested that the role of evolutionarily conserved edits is to compensate for harmful genomic substitutions, and that there is no added value in having an editable codon as compared with a restoration of the preferred genomic allele. Here, we show that this hypothesis fails to explain the evolutionary dynamics of recoding sites in coleoids. Instead, our results indicate that a large fraction of the shared, strongly recoded, sites in coleoids have been selected for proteome diversification, meaning that the fitness of an editable A is higher than an uneditable A or a genomically encoded G. en_US
dc.description.sponsorship This research was supported by a grants from the United States–Israel Binational Science Foundation (BSF), Jerusalem, Israel (BSF2017262 to J.J.C.R. and E.E.), the Israel Science Foundation (3371/20 to E.E.) and the National Science Foundation (IOS 1827509 and 1557748 to J.J.C.R). en_US
dc.identifier.citation Shoshan, Y., Liscovitch-Brauer, N., Rosenthal, J. J. C., & Eisenberg, E. (2021). Adaptive proteome diversification by nonsynonymous A-to-I RNA editing in coleoid cephalopods. Molecular Biology and Evolution, 38(9), 3775–3788. en_US
dc.identifier.doi 10.1093/molbev/msab154
dc.identifier.uri https://hdl.handle.net/1912/28045
dc.publisher Oxford University Press en_US
dc.relation.uri https://doi.org/10.1093/molbev/msab154
dc.rights Attribution 4.0 International *
dc.rights.uri http://creativecommons.org/licenses/by/4.0/ *
dc.subject RNA editing en_US
dc.subject Adaptation en_US
dc.subject Evolution en_US
dc.title Adaptive proteome diversification by nonsynonymous A-to-I RNA editing in coleoid cephalopods en_US
dc.type Article en_US
dspace.entity.type Publication
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relation.isAuthorOfPublication.latestForDiscovery cb4375cd-2672-4291-91e3-ecffb8575834
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