Maienschein
Jane
Maienschein
Jane
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ArticleExplaining regeneration: cells and limbs as complex living systems, learning from history(Frontiers Media, 2021-08-31) MacCord, Kate ; Maienschein, JaneRegeneration has been investigated since Aristotle, giving rise to many ways of explaining what this process is and how it works. Current research focuses on gene expression and cell signaling of regeneration within individual model organisms. We tend to look to model organisms on the reasoning that because of evolution, information gained from other species must in some respect be generalizable. However, for all that we have uncovered about how regeneration works within individual organisms, we have yet to translate what we have gleaned into achieving the goal of regenerative medicine: to harness and enhance our own regenerative abilities. Turning to history may provide a crucial perspective in advancing us toward this goal. History gives perspective, allowing us to reflect on how our predecessors did their work and what assumptions they made, thus also revealing limitations. History, then, may show us how we can move from our current reductionist thinking focused on particular selected model organisms toward generalizations about this crucial process that operates across complex living systems and move closer to repairing our own damaged bodies.
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ArticleUnderstanding regeneration at different scales.(eLife Sciences Publications, 2019-03-13) MacCord, Kate ; Maienschein, JaneRegeneration occurs at many different levels in nature, from individual organisms (notably earthworms and hydra), through communities of microbes, to ecosystems such as forests. Researchers in the life sciences and the history and philosophy of science are collaborating to explore how the processes of repair and recovery observed at these different scales are related.