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dc.contributor.authorKeikhosravi, Adib  Concept link
dc.contributor.authorLiu, Yuming  Concept link
dc.contributor.authorDrifka, Cole  Concept link
dc.contributor.authorWoo, Kaitlin M.  Concept link
dc.contributor.authorVerma, Amitabh  Concept link
dc.contributor.authorOldenbourg, Rudolf  Concept link
dc.contributor.authorEliceiri, Kevin  Concept link
dc.date.accessioned2017-09-28T15:40:52Z
dc.date.available2017-09-28T15:40:52Z
dc.date.issued2017-08-29
dc.identifier.citationBiomedical Optics Express 8 (2017): 4243-4256en_US
dc.identifier.urihttps://hdl.handle.net/1912/9255
dc.descriptionAuthor Posting. © The Optical Society, 2017. This article is posted here by permission of The Optical Society for personal use, not for redistribution. The definitive version was published in Biomedical Optics Express 8 (2017): 4243-4256, doi:10.1364/BOE.8.004243.en_US
dc.description.abstractA number of histopathology studies have utilized the label free microscopy method of Second Harmonic Generation (SHG) to investigate collagen organization in disease onset and progression. Here we explored an alternative label free imaging approach, LC-PolScope that is based on liquid crystal based polarized light imaging. We demonstrated that this more accessible technology has the ability to visualize all fibers of interest and has a good to excellent correlation between SHG and LC-PolScope measurements in fibrillar collagen orientation and alignment. This study supports that LC-PolScope is a viable alternative to SHG for label free collagen organization measurements in thin histology sections.en_US
dc.description.sponsorshipMorgridge Institute for Research and National Institutes of Health (NIH) (U54DK104310 and R01GM114274); The University of Wisconsin Carbone Cancer Center Cancer Center Biocore and Histology core (UWCCC) (P30 CA014520).en_US
dc.language.isoen_USen_US
dc.publisherThe Optical Societyen_US
dc.relation.urihttps://doi.org/10.1364/BOE.8.004243
dc.titleQuantification of collagen organization in histopathology samples using liquid crystal based polarization microscopyen_US
dc.typeArticleen_US
dc.identifier.doi10.1364/BOE.8.004243


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