The microbiome-mitochondrion connection : common ancestries, common mechanisms, common goals
MetadataShow full item record
KeywordSCFA; Butyrate; Ellagitannins; Lactate; Metabolic; Microbiome; Mitochondria; Muscle; Short-chain fatty acids; Urolithin A
Lynn Margulis in the 1960s elegantly proposed a shared phylogenetic history between bacteria and mitochondria; this relationship has since become a cornerstone of modern cellular biology. Yet, an interesting facet of the interaction between the microbiome and mitochondria has been mostly ignored, that of the systems biology relationship that underpins host health and longevity. The mitochondria are descendants of primordial aerobic pleomorphic bacteria (likely genus Rickettsia) that entered (literally and functionally) into a mutualistic partnership with ancient anaerobic microbes (likely Archaea). A stable symbiosis was established, given the metabolic versatility of the early mitochondria, which were capable of providing energy with or without oxygen, whereas nutrient gathering was the assumed responsibility of the host. While microbial relationships with single-cell protists must have occurred in the past, as they occur today, the evolution of multicellular organisms generated a new framework for symbiosis with the microbial world, taking the ancient partnership to an entirely new level. Cell-cell communication between microbes and single-cell protists was augmented through multicellularity to allow distant communication between the host cells and the microbiome, resulting in the development of complex metabolic relationships and an immune system to manage these interactions. Thus, the host is now the body and its resident mitochondria, and the microbiome is an essential supplier of metabolites that act at the level of mitochondria in skeletal muscle to stabilize host metabolism. We humans are caretakers of a profoundly vast and diverse microbiota, the majority of which resides in the gut. Indeed, the microbial genetic diversity of our microbiota outstrips our own by several orders of magnitude, and the cellular abundance is roughly equivalent to our somatic selves. Modern clinical science has elegantly highlighted the importance of the microbiome for metabolic health and well-being. This perspective underscores one fundamental facet of this symbiosis, the ancestral mitochondrion-microbiome axis.
© The Author(s), 2017. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in mSystems 2 (2017): e00018-17, doi:10.1128/mSystems.00018-17.
Suggested CitationArticle: Franco-Obregón, Alfredo, Gilbert, Jack A., "The microbiome-mitochondrion connection : common ancestries, common mechanisms, common goals", mSystems 2 (2017): e00018-17, DOI:10.1128/mSystems.00018-17, https://hdl.handle.net/1912/9237
The following license files are associated with this item:
Showing items related by title, author, creator and subject.
A common garden experiment with Porphyra umbilicalis (Rhodophyta) evaluates methods to study spatial differences in the macroalgal microbiome Quigley, Charlotte T. C.; Morrison, Hilary G.; Mendonça, Inara Regina; Brawley, Susan H. (2018-07)Macroalgal microbiomes are receiving deserved study, but there is little information about microbial spatial diversity across the thallus. Reliance on field material makes it difficult to discern whether recovered microbiomes ...
Aquarium microbiome response to ninety-percent system water change : clues to microbiome management Van Bonn, William; LaPointe, Allen; Gibbons, Sean M.; Frazier, Angel; Hampton-Marcell, Jarrad T.; Gilbert, Jack A. (2015-04)The bacterial community composition and structure of water from an established teleost fish system was examined before, during and after a major water change to explore the impact of such a water-change disturbance on the ...
Maternal diet during pregnancy is related with the infant stool microbiome in a delivery mode-dependent manner Lundgren, Sara N.; Madan, Juliette C.; Emond, Jennifer A.; Morrison, Hilary G.; Christensen, Brock C.; Karagas, Margaret R.; Hoen, Anne G. (BMC, 2018-07-05)The gut microbiome has an important role in infant health and immune development and may be affected by early-life exposures. Maternal diet may influence the infant gut microbiome through vertical transfer of maternal ...