Trade-off between transcriptome plasticity and genome evolution in cephalopods
Trade-off between transcriptome plasticity and genome evolution in cephalopods
Date
2017-03
Authors
Liscovitch-Brauer, Noa
Alon, Shahar
Porath, Hagit T.
Elstein, Boaz
Unger, Ron
Ziv, Tamar
Admon, Arie
Levanon, Erez
Rosenthal, Joshua J. C.
Eisenberg, Eli
Alon, Shahar
Porath, Hagit T.
Elstein, Boaz
Unger, Ron
Ziv, Tamar
Admon, Arie
Levanon, Erez
Rosenthal, Joshua J. C.
Eisenberg, Eli
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Keywords
Epitranscriptome
RNA modifications
RNA editing
ADAR
Neural plasticity
Cephalopods
Genome evolution
Proteome diversity
RNA modifications
RNA editing
ADAR
Neural plasticity
Cephalopods
Genome evolution
Proteome diversity
Abstract
RNA editing, a post-transcriptional process, allows the diversification of proteomes beyond the
genomic blueprint; however it is infrequently used among animals. Recent reports suggesting
increased levels of RNA editing in squids thus raise the question of their nature and effects in
these organisms. We here show that RNA editing is particularly common in behaviorally
sophisticated coleoid cephalopods, with tens of thousands of evolutionarily conserved sites.
Editing is enriched in the nervous system affecting molecules pertinent for excitability and
neuronal morphology. The genomic sequence flanking editing sites is highly conserved,
suggesting that the process confers a selective advantage. Due to the large number of sites, the
surrounding conservation greatly reduces the number of mutations and genomic polymorphisms
in protein coding regions. This trade-off between genome evolution and transcriptome plasticity
highlights the importance of RNA recoding as a strategy for diversifying proteins, particularly
those associated with neural function.
Description
Author Posting. © The Author(s), 2017. This is the author's version of the work. It is posted here by permission of Cell Press for personal use, not for redistribution. The definitive version was published in Cell 169 (2017): 191-202, doi:10.1016/j.cell.2017.03.025.