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    Trade-off between transcriptome plasticity and genome evolution in cephalopods

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    Author's manuscript, inc. tables S1-S3,S8,S9 and supplemental figures (16.39Mb)
    Tables S1–S3, S8, and S9 (203.5Kb)
    Table S4 (29.56Mb)
    Table S5 (109.5Mb)
    Table S6 (278.7Kb)
    Table S7 (13.82Mb)
    Table S10 (76.69Kb)
    Date
    2017-03
    Author
    Liscovitch-Brauer, Noa  Concept link
    Alon, Shahar  Concept link
    Porath, Hagit T.  Concept link
    Elstein, Boaz  Concept link
    Unger, Ron  Concept link
    Ziv, Tamar  Concept link
    Admon, Arie  Concept link
    Levanon, Erez  Concept link
    Rosenthal, Joshua J. C.  Concept link
    Eisenberg, Eli  Concept link
    Metadata
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    Citable URI
    https://hdl.handle.net/1912/8949
    As published
    https://doi.org/10.1016/j.cell.2017.03.025
    Keyword
     Epitranscriptome; RNA modifications; RNA editing; ADAR; Neural plasticity; Cephalopods; Genome evolution; Proteome diversity 
    Abstract
    RNA editing, a post-transcriptional process, allows the diversification of proteomes beyond the genomic blueprint; however it is infrequently used among animals. Recent reports suggesting increased levels of RNA editing in squids thus raise the question of their nature and effects in these organisms. We here show that RNA editing is particularly common in behaviorally sophisticated coleoid cephalopods, with tens of thousands of evolutionarily conserved sites. Editing is enriched in the nervous system affecting molecules pertinent for excitability and neuronal morphology. The genomic sequence flanking editing sites is highly conserved, suggesting that the process confers a selective advantage. Due to the large number of sites, the surrounding conservation greatly reduces the number of mutations and genomic polymorphisms in protein coding regions. This trade-off between genome evolution and transcriptome plasticity highlights the importance of RNA recoding as a strategy for diversifying proteins, particularly those associated with neural function.
    Description
    Author Posting. © The Author(s), 2017. This is the author's version of the work. It is posted here by permission of Cell Press for personal use, not for redistribution. The definitive version was published in Cell 169 (2017): 191-202, doi:10.1016/j.cell.2017.03.025.
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    • Bell Center Publications
    Suggested Citation
    Preprint: Liscovitch-Brauer, Noa, Alon, Shahar, Porath, Hagit T., Elstein, Boaz, Unger, Ron, Ziv, Tamar, Admon, Arie, Levanon, Erez, Rosenthal, Joshua J. C., Eisenberg, Eli, "Trade-off between transcriptome plasticity and genome evolution in cephalopods", 2017-03, https://doi.org/10.1016/j.cell.2017.03.025, https://hdl.handle.net/1912/8949
     

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