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dc.contributor.authorHu, Ruilong  Concept link
dc.contributor.authorFerguson, Katie A.  Concept link
dc.contributor.authorWhiteus, Christina  Concept link
dc.contributor.authorMeijer, Dimphna H.  Concept link
dc.contributor.authorAraneda, Ricardo C.  Concept link
dc.date.accessioned2016-11-21T20:00:22Z
dc.date.available2016-11-21T20:00:22Z
dc.date.issued2016-10-27
dc.identifier.citationeNeuro 3 (2016): e0197-16.2016en_US
dc.identifier.urihttps://hdl.handle.net/1912/8542
dc.description© The Author(s), 2016. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in eNeuro 3 (2016): e0197-16.2016, doi:10.1523/ENEURO.0197-16.2016.en_US
dc.description.abstractAn important contribution to neural circuit oscillatory dynamics is the ongoing activation and inactivation of hyperpolarization-activated currents (Ih). Network synchrony dynamics play an important role in the initial processing of odor signals by the main olfactory bulb (MOB) and accessory olfactory bulb (AOB). In the mouse olfactory bulb, we show that Ih is present in granule cells (GCs), the most prominent inhibitory neuron in the olfactory bulb, and that Ih underlies subthreshold resonance in GCs. In accord with the properties of Ih, the currents exhibited sensitivity to changes in extracellular K concentration and ZD7288 (4-ethylphenylamino-1,2-dimethyl-6-methylaminopyrimidin chloride), a blocker of Ih. ZD7288 also caused GCs to hyperpolarize and increase their input resistance, suggesting that Ih is active at rest in GCs. The inclusion of cAMP in the intracellular solution shifted the activation of Ih to less negative potentials in the MOB, but not in the AOB, suggesting that channels with different subunit composition mediate Ih in these regions. Furthermore, we show that mature GCs exhibit Ih-dependent subthreshold resonance in the theta frequency range (4–12 Hz). Another inhibitory subtype in the MOB, the periglomerular cells, exhibited Ih-dependent subthreshold resonance in the delta range (1–4 Hz), while principal neurons, the mitral cells, do not exhibit Ih-dependent subthreshold resonance. Importantly, Ih size, as well as the strength and frequency of resonance in GCs, exhibited a postnatal developmental progression, suggesting that this development of Ih in GCs may differentially contribute to their integration of sensory input and contribution to oscillatory circuit dynamics.en_US
dc.description.sponsorshipThis research was supported by National Institutes of Health (NIH)-National Institute on Deafness and Other Communication Disorders Grant DCR01-DC- 009817 and NIH-National Institute on Aging Grant AG-049937A (to R.C.A); and National Science Foundation-Graduate Research Fellowships Program/Division of Graduate Education Grant 1322106 (to R.H).en_US
dc.language.isoen_USen_US
dc.publisherSociety for Neuroscienceen_US
dc.relation.urihttps://doi.org/10.1523/ENEURO.0197-16.2016
dc.rightsAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectGranule cellen_US
dc.subjectHCNen_US
dc.subjectNeurogenesisen_US
dc.subjectOlfactory bulben_US
dc.subjectResonanceen_US
dc.titleHyperpolarization-activated currents and subthreshold resonance in granule cells of the olfactory bulben_US
dc.typeArticleen_US
dc.identifier.doi10.1523/ENEURO.0197-16.2016


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Attribution 4.0 International
Except where otherwise noted, this item's license is described as Attribution 4.0 International