The obese gut microbiome across the epidemiologic transition
Dugas, Lara R.
Gilbert, Jack A.
Layden, Brian T.
MetadataShow full item record
The obesity epidemic has emerged over the past few decades and is thought to be a result of both genetic and environmental factors. A newly identified factor, the gut microbiota, which is a bacterial ecosystem residing within the gastrointestinal tract of humans, has now been implicated in the obesity epidemic. Importantly, this bacterial community is impacted by external environmental factors through a variety of undefined mechanisms. We focus this review on how the external environment may impact the gut microbiota by considering, the host’s geographic location ‘human geography’, and behavioral factors (diet and physical activity). Moreover, we explore the relationship between the gut microbiota and obesity with these external factors. And finally, we highlight here how an epidemiologic model can be utilized to elucidate causal relationships between the gut microbiota and external environment independently and collectively, and how this will help further define this important new factor in the obesity epidemic.
© The Author(s), 2016. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Emerging Themes in Epidemiology 13 (2016): 2, doi:10.1186/s12982-015-0044-5.
Suggested CitationEmerging Themes in Epidemiology 13 (2016): 2
The following license files are associated with this item:
Showing items related by title, author, creator and subject.
Aquarium microbiome response to ninety-percent system water change : clues to microbiome management Van Bonn, William; LaPointe, Allen; Gibbons, Sean M.; Frazier, Angel; Hampton-Marcell, Jarrad T.; Gilbert, Jack A. (2015-04)The bacterial community composition and structure of water from an established teleost fish system was examined before, during and after a major water change to explore the impact of such a water-change disturbance on the ...
The premature infant gut microbiome during the first 6 weeks of life differs based on gestational maturity at birth Chernikova, Diana A.; Madan, Juliette C.; Housman, Molly L.; Zain-ul-abideen, Muhammad; Lundgren, Sara N.; Morrison, Hilary G.; Sogin, Mitchell L.; Williams, Scott M.; Moore, Jason H.; Karagas, Margaret R.; Hoen, Anne G. (Nature Publishing Group, 2018-05-23)The impact of degree of prematurity at birth on premature infant gut microbiota has not been extensively studied in comparison to term infants in large cohorts. To determine the effect of gestational age at birth and ...
Gibbons, Sean M.; Gilbert, Jack A. (2015-09-29)Microorganisms are the pillars of life on Earth. Over billions of years, they have evolved into every conceivable niche on the planet. Microbes reshaped the oceans and atmosphere and gave rise to conditions conducive to ...