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dc.contributor.authorJeffery, William R.  Concept link
dc.date.accessioned2015-12-29T15:35:52Z
dc.date.available2015-12-29T15:35:52Z
dc.date.issued2015-04
dc.identifier.urihttps://hdl.handle.net/1912/7705
dc.descriptionAuthor Posting. © The Author(s), 2015. This is the author's version of the work. It is posted here by permission of Elsevier for personal use, not for redistribution. The definitive version was published in International Review of Cell and Molecular Biology 319 (2015): 255-282, doi:10.1016/bs.ircmb.2015.06.005.en_US
dc.description.abstractRegeneration studies in the tunicate Ciona intestinalis have recently been focused on the potential of adult stem cells to replace injured tissues and organs during the adult life cycle using the oral siphon (OS) as a model. The OS has oral siphon pigment organs (OPO) along its rim and an underlying network of muscle fibers in its tube. Different regeneration processes are triggered by OS amputation at the tip, along the tube, or at the base. One process involves the replacement of OPO without new cell division by direct differentiation of locally deployed stem cells or stem cells that migrate from the branchial sac. Another process involves blastema formation by the migration of progenitor cells produced from branchial sac stem cells. The capacity for complete and accurate OS regeneration declines continuously during the adult life cycle. Finally, after an age threshold is reached, OS regeneration ceases in old animals. The loss of regeneration capacity in old animals involves the depletion of stem cells in the branchial sac, the inability of brachial sac progenitor cells to migrate to the sites of regeneration, and defective OPO replacement. The significance of the OS model for studying regeneration, stem cells, and aging will be enhanced by the application of molecular methods.en_US
dc.description.sponsorshipThis article was prepared under the auspices of a grant from the National Institutes of Heath (AG037918) and Frederick and Betsy Bang and Laura and Arthur Colwin Fellowships from the Marine Biological Laboratory, Woods Hole, MAen_US
dc.format.mimetypeapplication/pdf
dc.language.isoen_USen_US
dc.relation.urihttps://doi.org/10.1016/bs.ircmb.2015.06.005
dc.subjectCiona intestinalisen_US
dc.subjectOral siphonen_US
dc.subjectRegenerationen_US
dc.subjectAdult stem cellsen_US
dc.subjectProgenitor cellsen_US
dc.subjectBranchial sacen_US
dc.subjectBlastemaen_US
dc.subjectAgingen_US
dc.titleRegeneration, stem cells, and aging in the tunicate Ciona : insights from the oral siphonen_US
dc.typePreprinten_US


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