The MBL offers advanced, graduate-level courses in embryology, physiology, neurobiology, microbiology, reproduction, and parasitology .

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  • Reorganization of complex ciliary flows around regenerating Stentor coeruleus 

    Wan, Kirsty Y.; Hürlimann, Sylvia K.; Fenix, Aidan M.; McGillivary, Rebecca M.; Makushok, Tatyana; Burns, Evan; Sheung, Janet Y.; Marshall, Wallace F. (The Royal Society, 2019-12-30)
    The phenomenon of ciliary coordination has garnered increasing attention in recent decades and multiple theories have been proposed to explain its occurrence in different biological systems. While hydrodynamic interactions ...
  • Molecular profiling of single neurons of known identity in two ganglia from the crab Cancer borealis 

    Northcutt, Adam J.; Kick, Daniel R.; Otopalik, Adriane G; Goetz, Benjamin M.; Harris, Rayna M.; Santin, Joseph M.; Hofmann, Hans A.; Marder, Eve; Schulz, David J. (National Academy of Sciences, 2019-12-05)
    Understanding circuit organization depends on identification of cell types. Recent advances in transcriptional profiling methods have enabled classification of cell types by their gene expression. While exceptionally ...
  • Tetrodotoxin-sensitive sodium channels mediate action potential firing and excitability in menthol-sensitive Vglut3-lineage sensory neurons 

    Griffith, Theanne N.; Docter, Trevor A.; Lumpkin, Ellen A. (Society for Neuroscience, 2019-09-04)
    Small-diameter vesicular glutamate transporter 3-lineage (Vglut3lineage) dorsal root ganglion (DRG) neurons play an important role in mechanosensation and thermal hypersensitivity; however, little is known about their ...
  • Multisensory and motor representations in rat oral somatosensory cortex 

    Clemens, Ann M.; Fernandez Delgado, Yohami; Mehlman, Max L.; Mishra, Poonam; Brecht, Michael (Nature Publishing Group, 2018-09-10)
    In mammals, a complex array of oral sensors assess the taste, temperature and haptic properties of food. Although the representation of taste has been extensively studied in the gustatory cortex, it is unclear how the ...
  • Variation in traction forces during cell cycle progression 

    Vianay, Benoit; Senger, Fabrice; Alamos, Simon; Anjur-Dietrich, Maya; Bearce, Elizabeth; Cheeseman, Bevan; Lee, Lisa; Théry, Manuel (2017-10-31)
    Tissue morphogenesis results from the interplay between cell growth and mechanical forces. While the impact of forces on cell proliferation has been fairly well characterized, the inverse relationship is much less ...
  • The signaling lipid sphingosine 1-phosphate regulates mechanical pain 

    Hill, Rose Z.; Hoffman, Benjamin U.; Morita, Takeshi; Campos, Stephanie M.; Lumpkin, Ellen A.; Brem, Rachel B.; Bautista, Diana M. (eLife, 2018-03-21)
    Somatosensory neurons mediate responses to diverse mechanical stimuli, from innocuous touch to noxious pain. While recent studies have identified distinct populations of A mechanonociceptors (AMs) that are required for ...
  • Direction of actin flow dictates integrin LFA-1 orientation during leukocyte migration 

    Nordenfelt, Pontus; Moore, Travis I.; Mehta, Shalin B.; Kalappurakkal, Joseph Mathew; Swaminathan, Vinay; Koga, Nobuyasu; Lambert, Talley J.; Baker, David; Waters, Jennifer C.; Oldenbourg, Rudolf; Tani, Tomomi; Mayor, Satyajit; Waterman, Clare M.; Springer, Timothy (Nature Publishing Group, 2017-12-11)
    Integrin αβ heterodimer cell surface receptors mediate adhesive interactions that provide traction for cell migration. Here, we test whether the integrin, when engaged to an extracellular ligand and the cytoskeleton, adopts ...
  • Grasshopper DCMD : an undergraduate electrophysiology lab for investigating single-unit responses to behaviorally-relevant stimuli 

    Nguyen, Dieu My T.; Roper, Mark; Mircic, Stanislav; Olberg, Robert M.; Gage, Gregory J. (Faculty of Undergraduate Neuroscience, 2017-05)
    Avoiding capture from a fast-approaching predator is an important survival skill shared by many animals. Investigating the neural circuits that give rise to this escape behavior can provide a tractable demonstration of ...
  • Cell culture protocols, HeLa and CHO cells Woods Hole Physiology Course, 2006 

    Altman, David (Marine Biological Laboratory, 2006)
  • Hyperpolarization-activated currents and subthreshold resonance in granule cells of the olfactory bulb 

    Hu, Ruilong; Ferguson, Katie A.; Whiteus, Christina; Meijer, Dimphna H.; Araneda, Ricardo C. (Society for Neuroscience, 2016-10-27)
    An important contribution to neural circuit oscillatory dynamics is the ongoing activation and inactivation of hyperpolarization-activated currents (Ih). Network synchrony dynamics play an important role in the initial ...
  • Frontiers in Reproduction (FIR) : An assessment of success 

    Ascoli, Mario; Mebane, Dorianne; Fazleabas, Asgerally T. (Society for the Study of Reproduction, 2016-07-01)
    The Frontiers in Reproduction (FIR) course has been held annually since 1998 at the Marine Biological Laboratories in Woods Hole, MA. The primary purpose of the course is to train young reproductive biologists in cutting-edge ...
  • RCC1-dependent activation of Ran accelerates cell cycle and DNA repair, inhibiting DNA damage–induced cell senescence 

    Cekan, Pavol; Hasegawa, Keisuke; Pan, Yu; Tubman, Emily; Odde, David; Chen, Jin-Qiu; Herrmann, Michelle A.; Kumar, Sheetal; Kalab, Petr (American Society for Cell Biology, 2016-02-10)
    The coordination of cell cycle progression with the repair of DNA damage supports the genomic integrity of dividing cells. The function of many factors involved in DNA damage response (DDR) and the cell cycle depends on ...
  • DNA damage induces nuclear actin filament assembly by Formin-2 and Spire-1/2 that promotes efficient DNA repair 

    Belin, Brittany J.; Lee, Terri; Mullins, R. Dyche (eLife Sciences Publications, 2015-08-19)
    Actin filaments assemble inside the nucleus in response to multiple cellular perturbations, including heat shock, protein misfolding, integrin engagement, and serum stimulation. We find that DNA damage also generates ...
  • Sexually monomorphic maps and dimorphic responses in rat genital cortex 

    Lenschow, Constanze; Copley, Sean; Gardiner, Jayne M.; Talbot, Zoe N.; Vitenzon, Ariel; Brecht, Michael (2015-09)
    Mammalian external genitals show sexual dimorphism [1,2] and can change size and shape upon sexual arousal. Genitals feature prominently in the oldest pieces of figural art [3] and phallic depictions of penises informed ...
  • Spindle-to-cortex communication in cleaving, polyspermic Xenopus eggs 

    Field, Christine M.; Groen, Aaron C.; Nguyen, Phuong A.; Mitchison, Timothy J. (American Society for Cell Biology, 2015-10-15)
    Mitotic spindles specify cleavage planes in early embryos by communicating their position and orientation to the cell cortex using microtubule asters that grow out from the spindle poles during anaphase. Chromatin also ...
  • The nucleoporin ALADIN regulates Aurora A localization to ensure robust mitotic spindle formation 

    Carvalhal, Sara; Ribeiro, Susana Abreu; Arocena, Miguel; Kasciukovic, Taciana; Temme, Achim; Koehler, Katrin; Huebner, Angela; Griffis, Eric R. (American Society for Cell Biology, 2015-08-05)
    The formation of the mitotic spindle is a complex process that requires massive cellular reorganization. Regulation by mitotic kinases controls this entire process. One of these mitotic controllers is Aurora A kinase, which ...
  • Image analysis for biology 

    Kueh, Hao Yuan; Marco, Eugenio; Springer, Mike; Sivaramakrishnan, Sivaraj (2008-06)
  • Quantitative biology : where modern biology meets physical sciences 

    Shekhar, Shashank; Zhu, Lian; Mazutis, Linas; Sgro, Allyson E.; Fai, Thomas G.; Podolski, Marija (American Society for Cell Biology, 2014-11-05)
    Quantitative methods and approaches have been playing an increasingly important role in cell biology in recent years. They involve making accurate measurements to test a predefined hypothesis in order to compare experimental ...
  • Quantitative analysis and modeling of katanin function in flagellar length control 

    Kannegaard, Elisa; Rego, E. Hesper; Schuck, Sebastian; Feldman, Jessica L.; Marshall, Wallace F. (American Society for Cell Biology, 2014-08-20)
    Flagellar length control in Chlamydomonas reinhardtii provides a simple model system in which to investigate the general question of how cells regulate organelle size. Previous work demonstrated that Chlamydomonas cytoplasm ...
  • Self-organization of stabilized microtubules by both spindle and midzone mechanisms in Xenopus egg cytosol 

    Mitchison, Timothy J.; Nguyen, Phuong A.; Coughlin, Margaret; Groen, Aaron C. (American Society for Cell Biology, 2013-03-20)
    Previous study of self-organization of Taxol-stabilized microtubules into asters in Xenopus meiotic extracts revealed motor-dependent organizational mechanisms in the spindle. We revisit this approach using clarified cytosol ...

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