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dc.contributor.authorRipps, Harris  Concept link
dc.contributor.authorChappell, Richard L.  Concept link
dc.date.accessioned2014-10-16T15:43:50Z
dc.date.available2014-10-16T15:43:50Z
dc.date.issued2014-07-31
dc.identifier.citationMolecular Vision 20 (2014): 1067-1074en_US
dc.identifier.urihttps://hdl.handle.net/1912/6900
dc.description© The Author(s), 2014. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Molecular Vision 20 (2014): 1067-1074.en_US
dc.description.abstractThis review covers a broad range of topics related to the actions of zinc on the cells of the vertebrate retina. Much of this review relies on studies in which zinc was applied exogenously, and therefore the results, albeit highly suggestive, lack physiologic significance. This view stems from the fact that the concentrations of zinc used in these studies may not be encountered under the normal circumstances of life. This caveat is due to the lack of a zinc-specific probe with which to measure the concentrations of Zn2+ that may be released from neurons or act upon them. However, a great deal of relevant information has been garnered from studies in which Zn2+ was chelated, and the effects of its removal compared with findings obtained in its presence. For a more complete discussion of the consequences of depletion or excess in the body’s trace elements, the reader is referred to a recent review by Ugarte et al. in which they provide a detailed account of the interactions, toxicity, and metabolic activity of the essential trace elements iron, zinc, and copper in retinal physiology and disease. In addition, Smart et al. have published a splendid review on the modulation by zinc of inhibitory and excitatory amino acid receptor ion channels.en_US
dc.description.sponsorshipNSF Grant 1214162 and NIMHD/NIH Grant MD007599 (RLC)en_US
dc.format.mimetypeapplication/pdf
dc.language.isoen_USen_US
dc.publisherMolecular Visionen_US
dc.relation.urihttp://www.molvis.org/molvis/v20/1067
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Unported*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/
dc.titleReview : Zinc’s functional significance in the vertebrate retinaen_US
dc.typeArticleen_US


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