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dc.contributor.authorGribble, Kristin E.  Concept link
dc.contributor.authorJarvis, George  Concept link
dc.contributor.authorBock, Martha  Concept link
dc.contributor.authorMark Welch, David B.  Concept link
dc.identifier.citationAging Cell 13 (2014): 623–630en_US
dc.description© The Author(s), 2014. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Aging Cell 13 (2014): 623–630, doi:10.1111/acel.12217.en_US
dc.description.abstractWhile many studies have focused on the detrimental effects of advanced maternal age and harmful prenatal environments on progeny, little is known about the role of beneficial non-Mendelian maternal inheritance on aging. Here, we report the effects of maternal age and maternal caloric restriction (CR) on the life span and health span of offspring for a clonal culture of the monogonont rotifer Brachionus manjavacas. Mothers on regimens of chronic CR (CCR) or intermittent fasting (IF) had increased life span compared with mothers fed ad libitum (AL). With increasing maternal age, life span and fecundity of female offspring of AL-fed mothers decreased significantly and life span of male offspring was unchanged, whereas body size of both male and female offspring increased. Maternal CR partially rescued these effects, increasing the mean life span of AL-fed female offspring but not male offspring and increasing the fecundity of AL-fed female offspring compared with offspring of mothers of the same age. Both maternal CR regimens decreased male offspring body size, but only maternal IF decreased body size of female offspring, whereas maternal CCR caused a slight increase. Understanding the genetic and biochemical basis of these different maternal effects on aging may guide effective interventions to improve health span and life span.en_US
dc.description.sponsorshipThis work was supported by the National Institute on Aging Division of Aging Biology (R01 AG037960-01), the Ellison Medical Foundation/ American Federation for Aging Research Postdoctoral Fellows in Aging Research Program and a Neil Cornell Career Development Award.en_US
dc.publisherAnatomical Society and John Wiley & Sonsen_US
dc.rightsAttribution 3.0 Unported
dc.subjectCaloric restrictionen_US
dc.subjectMaternal effecten_US
dc.subjectMonogonont rotiferen_US
dc.titleMaternal caloric restriction partially rescues the deleterious effects of advanced maternal age on offspringen_US

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Attribution 3.0 Unported
Except where otherwise noted, this item's license is described as Attribution 3.0 Unported