Closing the wounds : one hundred and twenty five years of regenerative biology in the ascidian Ciona intestinalis
Citable URI
https://hdl.handle.net/1912/6756As published
https://doi.org/10.1002/dvg.22799Keyword
Partial body regeneration; Wounding; Tissue repair; Neural complex; Siphons; Oral siphon pigment organs; AgingAbstract
This year marks the 125th anniversary of the beginning of regeneration research in the
ascidian Ciona intestinalis. A brief note was published in 1891 reporting the regeneration
of the Ciona neural complex and siphons. This launched an active period of Ciona
regeneration research culminating in the demonstration of partial body regeneration: the
ability of proximal body parts to regenerate distal ones, but not vice versa. In a process
resembling regeneration, wounds in the siphon tube were discovered to result in the
formation of an ectopic siphon. Ciona regeneration research then lapsed into a period of
relative inactivity following the purported demonstration of the inheritance of acquired
characters using siphon regeneration as a model. Around the turn of the present century,
Ciona regeneration research experienced a new blossoming. The current studies
established the morphological and physiological integrity of the regeneration process and
its resemblance to ontogeny. They also determined some of the cell types responsible for
tissue and organ replacement and their sources in the body. Finally, they showed that
regenerative capacity is reduced with age. Many other aspects of regeneration now can be
studied at the mechanistic level because of the extensive molecular tools available in Ciona.
Description
Author Posting. © The Author(s), 2014. This is the author's version of the work. It is posted here by permission of John Wiley & Sons for personal use, not for redistribution. The definitive version was published in genesis 53 (2015): 48-65, doi:10.1002/dvg.22799.
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Suggested Citation
Preprint: Jeffery, William R., "Closing the wounds : one hundred and twenty five years of regenerative biology in the ascidian Ciona intestinalis", 2014-06, https://doi.org/10.1002/dvg.22799, https://hdl.handle.net/1912/6756Related items
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