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dc.contributor.authorChaikeeratisak, Vorrapon  Concept link
dc.contributor.authorTassanakajon, Anchalee  Concept link
dc.contributor.authorArmstrong, Peter B.  Concept link
dc.date.accessioned2014-05-07T15:57:34Z
dc.date.available2014-05-07T15:57:34Z
dc.date.issued2014-04-01
dc.identifier.citationBiological Bulletin 226 (2014): 102-110en_US
dc.identifier.urihttps://hdl.handle.net/1912/6608
dc.descriptionAuthor Posting. © Marine Biological Laboratory, 2014. This article is posted here by permission of Marine Biological Laboratory for personal use, not for redistribution. The definitive version was published in Biological Bulletin 226 (2014): 102-110.en_US
dc.description.abstractIn addition to its roles in hemostasis and wound repair, the blood clot plays an underappreciated role in innate immunity, where the established clot serves as a barrier to microbial penetration into the internal milieu and where the early clot entraps and immobilizes microbes that have entered wounds to the integuments. In this report we document the behavior of the pathogenic gram-negative bacterium Vibrio harveyi that has been entrapped in the fabric of the extracellular blood clot of one of its target organisms, the Pacific white shrimp, Litopenaeus vannamei. The freshly entrapped bacteria are held tightly by the clot, losing even Brownian motility, but by 1 h post-entrapment, a fraction of the bacteria have established small domains of fibrinolysis that enlarge progressively, enabling bacteria to escape from the clot's embrace. Escape is dependent on the actions of both serine- and metallo-proteases released from the bacterial cells.en_US
dc.description.sponsorshipThis research was financially supported by a student fellowship for Vorrapon Chaikeeratisak from the Royal Golden Jubilee Ph.D. program under the Thailand Research Fund (TRF) and by grant 0344360 from the National Science Foundation (PBA).en_US
dc.format.mimetypeapplication/pdf
dc.language.isoen_USen_US
dc.publisherMarine Biological Laboratoryen_US
dc.relation.urihttps://doi.org/10.1086/BBLv226n2p102
dc.titleInteraction of pathogenic vibrio bacteria with the blood clot of the Pacific white shrimp, Litopenaeus vannameien_US
dc.typeArticleen_US
dc.identifier.doi10.1086/BBLv226n2p102


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