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dc.contributor.authorJiang, Zheng  Concept link
dc.contributor.authorYang, Jinnan  Concept link
dc.contributor.authorPurpura, Lauren A.  Concept link
dc.contributor.authorLiu, Yufei  Concept link
dc.contributor.authorRipps, Harris  Concept link
dc.contributor.authorShen, Wen  Concept link
dc.date.accessioned2014-04-14T18:09:53Z
dc.date.available2014-04-14T18:09:53Z
dc.date.issued2013-09
dc.identifier.urihttps://hdl.handle.net/1912/6556
dc.descriptionAuthor Posting. © The Author(s), 2013. This is the author's version of the work. It is posted here by permission of the Physiological Society for personal use, not for redistribution. The definitive version was published in Journal of Physiology 592 (2014): 1479-1492, doi:10.1113/jphysiol.2013.265785.en_US
dc.description.abstractGlycine input originates with interplexiform cells, a group of neurons situated within the inner retina that transmit signals centrifugally to the distal retina. The effect on visual function of this novel mechanism is largely unknown. Using gramicidin-perforated patch whole-cell recordings, intracellular recordings, and specific antibody labeling techniques, we examined the effects of the synaptic connections between glycinergic interplexiform cells, photoreceptors, and bipolar cells. To confirm that interplexiform cells make centrifugal feedback on bipolar cell dendrites, we recorded the post-synaptic glycine currents from axon-detached bipolar cells while stimulating pre-synaptic interplexiform cells. The results show that glycinergic interplexiform cells activate bipolar cell dendrites that express the α3 subunit of the glycine receptor, as well as a subclass of unidentified receptors on photoreceptors. By virtue of their synaptic contacts, glycine centrifugal feedback increases glutamate release from photoreceptors, and suppresses the uptake of glutamate by the EAAT2 transporter on photoreceptors. The net effect is a significant increase in the synaptic gain between photoreceptors and their second-order neurons.en_US
dc.description.sponsorshipThis study was supported by grants from the National Science Foundation (NSF, IOS-1021646, WS) and the National Eye Institute (NEI, EY 14161, WS).en_US
dc.format.mimetypeapplication/pdf
dc.language.isoen_USen_US
dc.relation.urihttps://doi.org/10.1113/jphysiol.2013.265785
dc.subjectSalamander retinaen_US
dc.subjectGlycinergic interplexiform cellsen_US
dc.subjectSynaptic transmissionen_US
dc.titleGlycinergic feedback enhances synaptic gain in the distal retinaen_US
dc.typePreprinten_US


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