Now showing items 41-50 of 207
Differential gene expression between fall- and spring-run Chinook salmon assessed by long serial analysis of gene expression
(American Fisheries Society, 2008-09-15)
Of all Pacific salmonids, Chinook salmon Oncorhynchus tshawytscha display the greatest variability in return times to freshwater. The molecular mechanisms of these differential return times have not been well described. ...
Toward interoperable bioscience data
(Nature Publishing Group, 2012-01-27)
To make full use of research data, the bioscience community needs to adopt technologies and reward mechanisms that support interoperability and promote the growth of an open 'data commoning' culture. Here we describe the ...
The evolution of the four subunits of voltage-gated calcium channels : ancient roots, increasing complexity, and multiple losses
(Oxford University Press, 2014-08-21)
The alpha subunits of voltage-gated calcium channels (Cavs) are large transmembrane proteins responsible for crucial physiological processes in excitable cells. They are assisted by three auxiliary subunits that can modulate ...
The microbiome in pediatric cystic fibrosis patients : the role of shared environment suggests a window of intervention
(BioMed Central, 2014-04-28)
Cystic fibrosis (CF) is caused by mutations in the CFTR gene that predispose the airway to infection. Chronic infection by pathogens such as Pseudomonas aeruginosa leads to inflammation that gradually degrades lung function, ...
Repurposing human PDE4 inhibitors for neglected tropical diseases : design, synthesis and evaluation of cilomilast analogues as Trypanosoma brucei PDEB1 inhibitors
A medicinal chemistry exploration of the human phosphodiesterase 4 (hPDE4) inhibitor cilomilast (1) was undertaken in order to identify inhibitors of phosphodiesterase B1 of Trypanosoma brucei (TbrPDEB1). T. brucei is the ...
MIxS-BE : a MIxS extension defining a minimum information standard for sequence data from the built environment
(Nature Publishing Group, 2013-10-24)
The need for metadata standards for microbe sampling in the built environment.
Draft genome sequence of marine alphaproteobacterial strain HIMB11, the first cultivated representative of a unique lineage within the Roseobacter clade possessing an unusually small genome
(Genomic Standards Consortium, 2014)
Strain HIMB11 is a planktonic marine bacterium isolated from coastal seawater in Kaneohe Bay, Oahu, Hawaii belonging to the ubiquitous and versatile Roseobacter clade of the alphaproteobacterial family Rhodobacteraceae. ...
Physiology and molecular biology of aquatic cyanobacteria
(Frontiers Media, 2014-07-14)
Cyanobacteria thrive in every illuminated aquatic environment known, contributing at least 25% of primary productivity worldwide. Given their importance in carbon and nutrient cycles, cyanobacteria are essential geochemical ...
Maternal caloric restriction partially rescues the deleterious effects of advanced maternal age on offspring
(Anatomical Society and John Wiley & Sons, 2014-03-24)
While many studies have focused on the detrimental effects of advanced maternal age and harmful prenatal environments on progeny, little is known about the role of beneficial non-Mendelian maternal inheritance on aging. ...
Satellite remote sensing data can be used to model marine microbial metabolite turnover
(Nature Publishing Group, 2014-07-29)
Sampling ecosystems, even at a local scale, at the temporal and spatial resolution necessary to capture natural variability in microbial communities are prohibitively expensive. We extrapolated marine surface microbial ...