In vivo functional properties of juxtaglomerular neurons in the mouse olfactory bulb
Cohen, Lawrence B.
MetadataShow full item record
Juxtaglomerular neurons represent one of the largest cellular populations in the mammalian olfactory bulb yet their role for signal processing remains unclear. We used two-photon imaging and electrophysiological recordings to clarify the in vivo properties of these cells and their functional organization in the juxtaglomerular space. Juxtaglomerular neurons coded for many perceptual characteristics of the olfactory stimulus such as (1) identity of the odorant, (2) odorant concentration, (3) odorant onset, and (4) offset. The odor-responsive neurons clustered within a narrow area surrounding the glomerulus with the same odorant specificity, with ~80% of responding cells located ≤20 μm from the glomerular border. This stereotypic spatial pattern of activated cells persisted at different odorant concentrations and was found for neurons both activated and inhibited by the odorant. Our data identify a principal glomerulus with a narrow shell of juxtaglomerular neurons as a basic odor coding unit in the glomerular layer and underline the important role of intraglomerular circuitry.
© The Author(s), 2013. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Frontiers in Neural Circuits 7 (2013): 23, doi:10.3389/fncir.2013.00023.
Suggested CitationArticle: Homma, Ryota, Kovalchuk, Yuri, Konnerth, A., Cohen, Lawrence B., Garaschuk, Olga, "In vivo functional properties of juxtaglomerular neurons in the mouse olfactory bulb", Frontiers in Neural Circuits 7 (2013): 23, DOI:10.3389/fncir.2013.00023, https://hdl.handle.net/1912/5905
The following license files are associated with this item:
Showing items related by title, author, creator and subject.
Braubach, Oliver R.; Tombaz, Tuce; Geiller, Tristan; Homma, Ryota; Bozza, Thomas; Cohen, Lawrence B.; Choi, Yunsook (Nature Publishing Group, 2018-10-08)Glomeruli are the functional units of olfactory information processing but little remains known about their individual unit function. This is due to their widespread activation by odor stimuli. We expressed channelrhodopsin-2 ...
Hyperpolarization-activated currents and subthreshold resonance in granule cells of the olfactory bulb Hu, Ruilong; Ferguson, Katie A.; Whiteus, Christina; Meijer, Dimphna H.; Araneda, Ricardo C. (Society for Neuroscience, 2016-10-27)An important contribution to neural circuit oscillatory dynamics is the ongoing activation and inactivation of hyperpolarization-activated currents (Ih). Network synchrony dynamics play an important role in the initial ...
Perceptual stability during dramatic changes in olfactory bulb activation maps and dramatic declines in activation amplitudes Homma, Ryota; Cohen, Lawrence B.; Kosmidis, E. K.; Youngentob, S. L. (2007-03-30)We measured the concentration dependence of the ability of rats to identify odorants and compared these results with the calcium signals in the nerve terminals of the olfactory receptor neurons. Odorant identification ...