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dc.contributor.authorAmemiya, Chris T.  Concept link
dc.contributor.authorAlfoldi, Jessica  Concept link
dc.contributor.authorLee, Alison P.  Concept link
dc.contributor.authorFan, Shaohua  Concept link
dc.contributor.authorPhilippe, Herve  Concept link
dc.contributor.authorMacCallum, Iain  Concept link
dc.contributor.authorBraasch, Ingo  Concept link
dc.contributor.authorManousaki, Tereza  Concept link
dc.contributor.authorSchneider, Igor  Concept link
dc.contributor.authorRohner, Nicolas  Concept link
dc.contributor.authorOrgan, Chris  Concept link
dc.contributor.authorChalopin, Domitille  Concept link
dc.contributor.authorSmith, Jeramiah J.  Concept link
dc.contributor.authorRobinson, Mark  Concept link
dc.contributor.authorDorrington, Rosemary A.  Concept link
dc.contributor.authorGerdol, Marco  Concept link
dc.contributor.authorAken, Bronwen  Concept link
dc.contributor.authorAssunta Biscotti, Maria  Concept link
dc.contributor.authorBarucca, Marco  Concept link
dc.contributor.authorBaurain, Denis  Concept link
dc.contributor.authorBerlin, Aaron M.  Concept link
dc.contributor.authorBlatch, Gregory L.  Concept link
dc.contributor.authorBuonocore, Francesco  Concept link
dc.contributor.authorBurmester, Thorsten  Concept link
dc.contributor.authorCampbell, Michael S.  Concept link
dc.contributor.authorCanapa, Adriana  Concept link
dc.contributor.authorCannon, John P.  Concept link
dc.contributor.authorChristoffels, Alan  Concept link
dc.contributor.authorDe Moro, Gianluca  Concept link
dc.contributor.authorEdkins, Adrienne L.  Concept link
dc.contributor.authorFan, Lin  Concept link
dc.contributor.authorFausto, Anna Maria  Concept link
dc.contributor.authorFeiner, Nathalie  Concept link
dc.contributor.authorForconi, Mariko  Concept link
dc.contributor.authorGamieldien, Junaid  Concept link
dc.contributor.authorGnerre, Sante  Concept link
dc.contributor.authorGnirke, Andreas  Concept link
dc.contributor.authorGoldstone, Jared V.  Concept link
dc.contributor.authorHaerty, Wilfried  Concept link
dc.contributor.authorHahn, Mark E.  Concept link
dc.contributor.authorHesse, Uljana  Concept link
dc.contributor.authorHoffmann, Steve  Concept link
dc.contributor.authorJohnson, Jeremy  Concept link
dc.contributor.authorKarchner, Sibel I.  Concept link
dc.contributor.authorKuraku, Shigehiro  Concept link
dc.contributor.authorLara, Marcia  Concept link
dc.contributor.authorLevin, Joshua Z.  Concept link
dc.contributor.authorLitman, Gary W.  Concept link
dc.contributor.authorMauceli, Evan  Concept link
dc.contributor.authorMiyake, Tsutomu  Concept link
dc.contributor.authorMueller, M. Gail  Concept link
dc.contributor.authorNelson, David R.  Concept link
dc.contributor.authorNitsche, Anne  Concept link
dc.contributor.authorOlmo, Ettore  Concept link
dc.contributor.authorOta, Tatsuya  Concept link
dc.contributor.authorPallavicini, Alberto  Concept link
dc.contributor.authorPanji, Sumir  Concept link
dc.contributor.authorPicone, Barbara  Concept link
dc.contributor.authorPonting, Chris P.  Concept link
dc.contributor.authorProhaska, Sonja J.  Concept link
dc.contributor.authorPrzybylski, Dariusz  Concept link
dc.contributor.authorRatan Saha, Nil  Concept link
dc.contributor.authorRavi, Vydianathan  Concept link
dc.contributor.authorRibeiro, Filipe J.  Concept link
dc.contributor.authorSauka-Spengler, Tatjana  Concept link
dc.contributor.authorScapigliati, Giuseppe  Concept link
dc.contributor.authorSearle, Stephen M. J.  Concept link
dc.contributor.authorSharpe, Ted  Concept link
dc.contributor.authorSimakov, Oleg  Concept link
dc.contributor.authorStadler, Peter F.  Concept link
dc.contributor.authorStegeman, John J.  Concept link
dc.contributor.authorSumiyama, Kenta  Concept link
dc.contributor.authorTabbaa, Diana  Concept link
dc.contributor.authorTafer, Hakim  Concept link
dc.contributor.authorTurner-Maier, Jason  Concept link
dc.contributor.authorvan Heusden, Peter  Concept link
dc.contributor.authorWhite, Simon  Concept link
dc.contributor.authorWilliams, Louise  Concept link
dc.contributor.authorYandell, Mark  Concept link
dc.contributor.authorBrinkmann, Henner  Concept link
dc.contributor.authorVolff, Jean-Nicolas  Concept link
dc.contributor.authorTabin, Clifford J.  Concept link
dc.contributor.authorShubin, Neil  Concept link
dc.contributor.authorSchartl, Manfred  Concept link
dc.contributor.authorJaffe, David B.  Concept link
dc.contributor.authorPostlethwait, John H.  Concept link
dc.contributor.authorVenkatesh, Byrappa  Concept link
dc.contributor.authorDi Palma, Federica  Concept link
dc.contributor.authorLander, Eric S.  Concept link
dc.contributor.authorMeyer, Axel  Concept link
dc.contributor.authorLindblad-Toh, Kerstin  Concept link
dc.identifier.citationNature 496 (2013): 311-316en_US
dc.description© The Author(s), 2013. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Nature 496 (2013): 311-316, doi:10.1038/nature12027.en_US
dc.description.abstractThe discovery of a living coelacanth specimen in 1938 was remarkable, as this lineage of lobe-finned fish was thought to have become extinct 70 million years ago. The modern coelacanth looks remarkably similar to many of its ancient relatives, and its evolutionary proximity to our own fish ancestors provides a glimpse of the fish that first walked on land. Here we report the genome sequence of the African coelacanth, Latimeria chalumnae. Through a phylogenomic analysis, we conclude that the lungfish, and not the coelacanth, is the closest living relative of tetrapods. Coelacanth protein-coding genes are significantly more slowly evolving than those of tetrapods, unlike other genomic features. Analyses of changes in genes and regulatory elements during the vertebrate adaptation to land highlight genes involved in immunity, nitrogen excretion and the development of fins, tail, ear, eye, brain and olfaction. Functional assays of enhancers involved in the fin-to-limb transition and in the emergence of extra-embryonic tissues show the importance of the coelacanth genome as a blueprint for understanding tetrapod evolution.en_US
dc.description.sponsorshipcquisition and storage of Latimeria chalumnae samples was supported by grants from the African Coelacanth Ecosystem Programme of the South African National Department of Science and Technology. Generation of the Latimeria chalumnae and Protopterus annectens sequences by the Broad Institute of the Massachusetts Institute of Technology (MIT) and Harvard University was supported by grants from the National Human Genome Research Institute (NHGRI). K.L.T. is the recipient of a EURYI award from the European Science Foundation.en_US
dc.publisherNature Publishing Groupen_US
dc.rightsAttribution-NonCommercial-ShareAlike 3.0 Unported*
dc.subjectGenome evolutionen_US
dc.subjectComparative genomicsen_US
dc.titleThe African coelacanth genome provides insights into tetrapod evolutionen_US

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