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dc.contributor.authorQian, Haohua
dc.contributor.authorChappell, Richard L.
dc.contributor.authorRedenti, Stephen
dc.contributor.authorRipps, Harris
dc.date.accessioned2006-02-13T19:43:59Z
dc.date.available2006-02-13T19:43:59Z
dc.date.issued2004-12
dc.identifier.citationBiological Bulletin 207 (2004): 191-194en
dc.identifier.urihttp://hdl.handle.net/1912/562
dc.descriptionAuthor Posting. © Marine Biological Laboratory, 2004. This article is posted here by permission of Marine Biological Laboratory for personal use, not for redistribution. The definitive version was published in Biological Bulletin 207 (2004): 191-194.
dc.description.abstractBipolar cells in the vertebrate retina are second-order neurons that convey visual information from photoreceptors to ganglion cells, the neurons that relay the message to the brain. Bipolar cells consist typically of multiple subtypes that differ in their morphology, synaptic connections, and response properties. The individual subtypes are thought to carry different aspects of the visual signal through the retina, and they often exhibit unique membrane properties and neurotransmitter receptors. In the all-rod skate retina, only two morphologically and pharmacologically distinct subtypes of bipolar cell have been identified thus far. The large-field bipolar cells, with extensive dendritic arbors, are glycine-insensitive, whereas the small-field bipolar cells, which have only one or two dendritic branches, are sensitive to glycine. In the present study, we explored further the membrane properties of these two subtypes of skate bipolar cell with emphasis on the voltage-sensitive potassium currents. Our results show that the cells exhibit different voltage-activated current profiles, suggesting that the signals they transmit contain different features of the visual scene.en
dc.description.sponsorshipThis study was supported in part by NIH Grant EY-12028 (HQ); Fight for Sight, PSC/CUNY Grant 66257-0035, and NCRR/NIH RCMI Award RR-03037 (RLC); NIH Grant EY-06516 and a Senior Research Investigator Award from Research to Prevent Blindness (HR).en
dc.format.extent1926525 bytes
dc.format.mimetypeapplication/pdf
dc.language.isoen_USen
dc.publisherMarine Biological Laboratoryen
dc.relation.urihttp://www.biolbull.org/content/207/3/191.short
dc.titlePotassium currents distinguish the two subtypes of morphologically distinct skate bipolar cellsen
dc.typeArticleen


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