Potassium currents distinguish the two subtypes of morphologically distinct skate bipolar cells


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dc.contributor.author Qian, Haohua
dc.contributor.author Chappell, Richard L.
dc.contributor.author Redenti, Stephen
dc.contributor.author Ripps, Harris
dc.date.accessioned 2006-02-13T19:43:59Z
dc.date.available 2006-02-13T19:43:59Z
dc.date.issued 2004-12
dc.identifier.citation Biological Bulletin 207 (2004): 191-194 en
dc.identifier.uri http://hdl.handle.net/1912/562
dc.description Author Posting. © Marine Biological Laboratory, 2004. This article is posted here by permission of Marine Biological Laboratory for personal use, not for redistribution. The definitive version was published in Biological Bulletin 207 (2004): 191-194.
dc.description.abstract Bipolar cells in the vertebrate retina are second-order neurons that convey visual information from photoreceptors to ganglion cells, the neurons that relay the message to the brain. Bipolar cells consist typically of multiple subtypes that differ in their morphology, synaptic connections, and response properties. The individual subtypes are thought to carry different aspects of the visual signal through the retina, and they often exhibit unique membrane properties and neurotransmitter receptors. In the all-rod skate retina, only two morphologically and pharmacologically distinct subtypes of bipolar cell have been identified thus far. The large-field bipolar cells, with extensive dendritic arbors, are glycine-insensitive, whereas the small-field bipolar cells, which have only one or two dendritic branches, are sensitive to glycine. In the present study, we explored further the membrane properties of these two subtypes of skate bipolar cell with emphasis on the voltage-sensitive potassium currents. Our results show that the cells exhibit different voltage-activated current profiles, suggesting that the signals they transmit contain different features of the visual scene. en
dc.description.sponsorship This study was supported in part by NIH Grant EY-12028 (HQ); Fight for Sight, PSC/CUNY Grant 66257-0035, and NCRR/NIH RCMI Award RR-03037 (RLC); NIH Grant EY-06516 and a Senior Research Investigator Award from Research to Prevent Blindness (HR). en
dc.format.extent 1926525 bytes
dc.format.mimetype application/pdf
dc.language.iso en_US en
dc.publisher Marine Biological Laboratory en
dc.relation.uri http://www.biolbull.org/content/207/3/191.short
dc.title Potassium currents distinguish the two subtypes of morphologically distinct skate bipolar cells en
dc.type Article en

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