Convergent evolution of sodium ion selectivity in metazoan neuronal signaling


a service of the MBLWHOI Library | About WHOAS

Show simple item record

dc.contributor.author Barzilai, Maya Gur
dc.contributor.author Reitzel, Adam M.
dc.contributor.author Kraus, Johanna E. M.
dc.contributor.author Gordon, Dalia
dc.contributor.author Technau, Ulrich
dc.contributor.author Gurevitz, Michael
dc.contributor.author Moran, Yehu
dc.date.accessioned 2012-11-28T20:44:06Z
dc.date.available 2012-11-28T20:44:06Z
dc.date.issued 2012-08-30
dc.identifier.citation Cell Reports 2 (2012): 242–248 en_US
dc.identifier.uri http://hdl.handle.net/1912/5590
dc.description © The Author(s), 2012. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Cell Reports 2 (2012): 242–248, doi:10.1016/j.celrep.2012.06.016. en_US
dc.description.abstract Ion selectivity of metazoan voltage-gated Na+ channels is critical for neuronal signaling and has long been attributed to a ring of four conserved amino acids that constitute the ion selectivity filter (SF) at the channel pore. Yet, in addition to channels with a preference for Ca2+ ions, the expression and characterization of Na+ channel homologs from the sea anemone Nematostella vectensis, a member of the early-branching metazoan phylum Cnidaria, revealed a sodium-selective channel bearing a noncanonical SF. Mutagenesis and physiological assays suggest that pore elements additional to the SF determine the preference for Na+ in this channel. Phylogenetic analysis assigns the Nematostella Na+-selective channel to a channel group unique to Cnidaria, which diverged >540 million years ago from Ca2+-conducting Na+ channel homologs. The identification of Cnidarian Na+-selective ion channels distinct from the channels of bilaterian animals indicates that selectivity for Na+ in neuronal signaling emerged independently in these two animal lineages. en_US
dc.description.sponsorship This study was supported by a research grant from the Austrian National Science Foundation (FWF P 21108-B17) to U.T., and by a United States-Israel Binational Agricultural Research and Development Grant (IS-4313-10) and an Israeli Science Foundation grant (107/08) to M.G. en_US
dc.format.mimetype application/pdf
dc.language.iso en en_US
dc.publisher Cell Press en_US
dc.relation.uri http://dx.doi.org/10.1016/j.celrep.2012.06.016
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/3.0/ *
dc.title Convergent evolution of sodium ion selectivity in metazoan neuronal signaling en_US
dc.type Article en_US
dc.identifier.doi 10.1016/j.celrep.2012.06.016

Files in this item

The following license files are associated with this item:

This item appears in the following Collection(s)

Show simple item record

http://creativecommons.org/licenses/by-nc-nd/3.0/ Except where otherwise noted, this item's license is described as http://creativecommons.org/licenses/by-nc-nd/3.0/

Search WHOAS


My Account