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dc.contributor.authorBarzilai, Maya Gur
dc.contributor.authorReitzel, Adam M.
dc.contributor.authorKraus, Johanna E. M.
dc.contributor.authorGordon, Dalia
dc.contributor.authorTechnau, Ulrich
dc.contributor.authorGurevitz, Michael
dc.contributor.authorMoran, Yehu
dc.identifier.citationCell Reports 2 (2012): 242–248en_US
dc.description© The Author(s), 2012. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Cell Reports 2 (2012): 242–248, doi:10.1016/j.celrep.2012.06.016.en_US
dc.description.abstractIon selectivity of metazoan voltage-gated Na+ channels is critical for neuronal signaling and has long been attributed to a ring of four conserved amino acids that constitute the ion selectivity filter (SF) at the channel pore. Yet, in addition to channels with a preference for Ca2+ ions, the expression and characterization of Na+ channel homologs from the sea anemone Nematostella vectensis, a member of the early-branching metazoan phylum Cnidaria, revealed a sodium-selective channel bearing a noncanonical SF. Mutagenesis and physiological assays suggest that pore elements additional to the SF determine the preference for Na+ in this channel. Phylogenetic analysis assigns the Nematostella Na+-selective channel to a channel group unique to Cnidaria, which diverged >540 million years ago from Ca2+-conducting Na+ channel homologs. The identification of Cnidarian Na+-selective ion channels distinct from the channels of bilaterian animals indicates that selectivity for Na+ in neuronal signaling emerged independently in these two animal lineages.en_US
dc.description.sponsorshipThis study was supported by a research grant from the Austrian National Science Foundation (FWF P 21108-B17) to U.T., and by a United States-Israel Binational Agricultural Research and Development Grant (IS-4313-10) and an Israeli Science Foundation grant (107/08) to M.G.en_US
dc.publisherCell Pressen_US
dc.titleConvergent evolution of sodium ion selectivity in metazoan neuronal signalingen_US

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