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dc.contributor.authorBarzilai, Maya Gur  Concept link
dc.contributor.authorReitzel, Adam M.  Concept link
dc.contributor.authorKraus, Johanna E. M.  Concept link
dc.contributor.authorGordon, Dalia  Concept link
dc.contributor.authorTechnau, Ulrich  Concept link
dc.contributor.authorGurevitz, Michael  Concept link
dc.contributor.authorMoran, Yehu  Concept link
dc.identifier.citationCell Reports 2 (2012): 242–248en_US
dc.description© The Author(s), 2012. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Cell Reports 2 (2012): 242–248, doi:10.1016/j.celrep.2012.06.016.en_US
dc.description.abstractIon selectivity of metazoan voltage-gated Na+ channels is critical for neuronal signaling and has long been attributed to a ring of four conserved amino acids that constitute the ion selectivity filter (SF) at the channel pore. Yet, in addition to channels with a preference for Ca2+ ions, the expression and characterization of Na+ channel homologs from the sea anemone Nematostella vectensis, a member of the early-branching metazoan phylum Cnidaria, revealed a sodium-selective channel bearing a noncanonical SF. Mutagenesis and physiological assays suggest that pore elements additional to the SF determine the preference for Na+ in this channel. Phylogenetic analysis assigns the Nematostella Na+-selective channel to a channel group unique to Cnidaria, which diverged >540 million years ago from Ca2+-conducting Na+ channel homologs. The identification of Cnidarian Na+-selective ion channels distinct from the channels of bilaterian animals indicates that selectivity for Na+ in neuronal signaling emerged independently in these two animal lineages.en_US
dc.description.sponsorshipThis study was supported by a research grant from the Austrian National Science Foundation (FWF P 21108-B17) to U.T., and by a United States-Israel Binational Agricultural Research and Development Grant (IS-4313-10) and an Israeli Science Foundation grant (107/08) to M.G.en_US
dc.publisherCell Pressen_US
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Unported*
dc.titleConvergent evolution of sodium ion selectivity in metazoan neuronal signalingen_US

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