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dc.contributor.authorMiyazaki, Kenichi
dc.contributor.authorManita, Satoshi
dc.contributor.authorRoss, William N.
dc.date.accessioned2012-09-21T15:44:28Z
dc.date.available2012-09-21T15:44:28Z
dc.date.issued2012-08
dc.identifier.urihttp://hdl.handle.net/1912/5382
dc.descriptionAuthor Posting. © The Author(s), 2012. This is the author's version of the work. It is posted here by permission of Elsevier B.V. for personal use, not for redistribution. The definitive version was published in Cell Calcium 52 (2012): 422-432, doi:10.1016/j.ceca.2012.08.001.en_US
dc.description.abstractRecent experiments demonstrate that localized spontaneous Ca2+ release events can be detected in the dendrites of pyramidal cells in the hippocampus and other neurons (J. Neurosci. 29:7833-7845, 2009). These events have some properties that resemble ryanodine receptor mediated “sparks” in myocytes, and some that resemble IP3 receptor mediated “puffs” in oocytes. They can be detected in the dendrites of rats of all tested ages between P3 and P80 (with sparser sampling in older rats), suggesting that they serve a general signaling function and are not just important in development. However, in younger rats the amplitudes of the events are larger than the amplitudes in older animals and almost as large as the amplitudes of Ca2+ signals from backpropagating action potentials (bAPs). The rise time of the event signal is fast at all ages and is comparable to the rise time of the bAP fluorescence signal at the same dendritic location. The decay time is slower in younger animals, primarily because of weaker Ca2+ extrusion mechanisms at that age. Diffusion away from a brief localized source is the major determinant of decay at all ages. A simple computational model closely simulates these events with extrusion rate the only age dependent variable.en_US
dc.description.sponsorshipSupported in part by NIH grant NS-016295.en_US
dc.format.mimetypeapplication/pdf
dc.language.isoen_USen_US
dc.relation.urihttps://doi.org/10.1016/j.ceca.2012.08.001
dc.titleDevelopmental profile of localized spontaneous Ca2+ release events in the dendrites of rat hippocampal pyramidal neuronsen_US
dc.typePreprinten_US


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