Now showing items 1-3 of 3

  • Directly probing the mechanical properties of the spindle and its matrix 

    Gatlin, Jesse C.; Matov, Alexandre; Danuser, Gaudenz; Mitchison, Timothy J.; Salmon, Edward D. (Rockefeller University Press, 2010-02-22)
    Several recent models for spindle length regulation propose an elastic pole to pole spindle matrix that is sufficiently strong to bear or antagonize forces generated by microtubules and microtubule motors. We tested this ...
  • Functional overlap of microtubule assembly factors in chromatin-promoted spindle assembly 

    Groen, Aaron C.; Maresca, Thomas J.; Gatlin, Jesse C.; Salmon, Edward D.; Mitchison, Timothy J. (American Society for Cell Biology, 2009-04-15)
    Distinct pathways from centrosomes and chromatin are thought to contribute in parallel to microtubule nucleation and stabilization during animal cell mitotic spindle assembly, but their full mechanisms are not known. We ...
  • Spindle assembly in the absence of a RanGTP gradient requires localized CPC activity 

    Maresca, Thomas J.; Groen, Aaron C.; Gatlin, Jesse C.; Ohi, Ryoma; Mitchison, Timothy J.; Salmon, Edward D. (2009-05)
    During animal cell division, a gradient of GTP-bound Ran is generated around mitotic chromatin. It is generally accepted that this RanGTP gradient is essential for organizing the spindle since it locally activates critical ...