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Cellular Dynamics Program

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Cellular Dynamics Program

 

The Cellular Dynamics Program (CDP) at the MBL aims to accelerate the knowledge of basic biology and disease through the development and application of biophysical methods customized to shed light on life’s most essential processes.

CDP is composed of several independent laboratories, notably those with a specialization in imaging and cell physiology and biochemistry. Additionally the program houses the NIH:NCRR national resource, the BioCurrents Research Center. The CDP imaging component focuses on the architectural dynamics of living cells, which encompass the timely and coordinated assembly and disassembly of macromolecular structures essential for the proper functioning and differentiation of cells, the spatial and temporal organization of these structures, and their physiological and genetic control. The molecular physiology component, in pursuing studies of cell metabolism and transport biophysics, has pioneered the use of electrochemical sensors to define the chemical signatures surrounding living cells and tissues, opening insights to cell function from a distance.

Recent Submissions

  • Bridges, Andrew A.; Zhang, Huaiying; Mehta, Shalin B.; Occhipinti, Patricia; Tani, Tomomi; Gladfelter, Amy S. (2013-12)
    Septins assemble into filaments and higher-order structures that act as scaffolds for diverse cell functions including cytokinesis, cell polarity, and membrane remodeling. Despite their conserved role in cell organization, ...
  • Nozaki, Tadasu; Kaizu, Kazunari; Pack, Chan-Gi; Tamura, Sachiko; Tani, Tomomi; Hihara, Saera; Nagai, Takeharu; Takahashi, Koichi; Maeshima, Kazuhiro (Landes Bioscience, 2013-08-12)
    Genomic DNA is organized three dimensionally within cells as chromatin and is searched and read by various proteins by an unknown mechanism; this mediates diverse cell functions. Recently, several pieces of evidence, ...
  • Shribak, Michael (Optical Society of America, 2013-03-27)
    We describe a quantitative orientation-independent differential interference contrast (DIC) microscope, which allows bias retardation to be modulated and shear directions to be switched rapidly without any mechanical ...
  • Oldenbourg, Rudolf (2003-11)
    In the current chapter we describe the use of a new type of polarized light microscope which we started to develop at the Marine Biological Laboratory about ten years ago. The new “PolScope” is based on the traditional ...
  • Koike-Tani, Maki; Tani, Tomomi; Mehta, Shalin B.; Verma, Amitabh; Oldenbourg, Rudolf (2013-05)
    The polarized light microscope reveals orientational order in native molecular structures inside living cells, tissues, and whole organisms. Therefore, it is a powerful tool to monitor and analyze the early developmental ...