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    Xenopus staufen2 is required for anterior endodermal organ formation

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    Staufen2-Final.pdf (453.0Kb)
    Date
    2011-11
    Author
    Bilogan, Cassandra K.  Concept link
    Horb, Marko E.  Concept link
    Metadata
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    Citable URI
    https://hdl.handle.net/1912/5111
    As published
    https://doi.org/10.1002/dvg.22000
    Keyword
     Pancreas; RNA binding protein; Organizer; BMP; Morpholino 
    Abstract
    Defining the regulatory molecular networks involved in patterning the developing anterior endoderm is essential to understanding how the pancreas, liver, stomach and duodenum are discretely specified from each other. In this study, we analyzed the expression and function of the double-stranded RNA-binding protein Staufen2 in Xenopus laevis endoderm. We found that staufen2 was broadly expressed within the developing endoderm beginning at gastrulation becoming localized to the anterior endoderm at later stages. Through morpholino-mediated knockdown, we demonstrate that Staufen2 function is required for proper formation of the stomach, liver and pancreas. We define that its function is required during gastrulation for proper patterning of the dorsal-ventral axis and that it acts to regulate expression of BMP signaling components.
    Description
    Author Posting. © The Author(s), 2011. This is the author's version of the work. It is posted here by permission of John Wiley & Sons for personal use, not for redistribution. The definitive version was published in genesis 50 (2012): 251-259, doi:10.1002/dvg.22000.
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    • Bell Center Publications
    Suggested Citation
    Preprint: Bilogan, Cassandra K., Horb, Marko E., "Xenopus staufen2 is required for anterior endodermal organ formation", 2011-11, https://doi.org/10.1002/dvg.22000, https://hdl.handle.net/1912/5111
     

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