Xenopus staufen2 is required for anterior endodermal organ formation
MetadataShow full item record
Defining the regulatory molecular networks involved in patterning the developing anterior endoderm is essential to understanding how the pancreas, liver, stomach and duodenum are discretely specified from each other. In this study, we analyzed the expression and function of the double-stranded RNA-binding protein Staufen2 in Xenopus laevis endoderm. We found that staufen2 was broadly expressed within the developing endoderm beginning at gastrulation becoming localized to the anterior endoderm at later stages. Through morpholino-mediated knockdown, we demonstrate that Staufen2 function is required for proper formation of the stomach, liver and pancreas. We define that its function is required during gastrulation for proper patterning of the dorsal-ventral axis and that it acts to regulate expression of BMP signaling components.
Author Posting. © The Author(s), 2011. This is the author's version of the work. It is posted here by permission of John Wiley & Sons for personal use, not for redistribution. The definitive version was published in genesis 50 (2012): 251-259, doi:10.1002/dvg.22000.
Showing items related by title, author, creator and subject.
Marine sedimentary organic matter : delineation of marine and terrestrial sources through radiocarbon dating; and the role of organic sulfur in early petroleum generation Benitez-Nelson, Bryan C. (Massachusetts Institute of Technology and Woods Hole Oceanographic Institution, 1996-05)This thesis details two years of research conducted with the guidance and support of three advisors: Dr. J. K. Whelan, Dr. J. S. Seewald and Dr. T. I. Eglinton. Each of the three chapters represents a different, ...
Transport of organic carbon from the California coast to the slope region : a study of Δ14C and δ13C signatures of organic compound classes Hwang, Jeomshik; Druffel, Ellen R. M.; Komada, Tomoko (American Geophysical Union, 2005-05-05)Surface sediments along a transect from an abyssal site in the northeastern Pacific (Station M, 34°50′N, 123°00′W) to a small mountainous river on the California coast (Santa Clara River) were studied to investigate the ...
Persistent organic pollutants (POPs), polycyclic aromatic hydrocarbons (PAHs), and plastics : examples of the status, trend, and cycling of organic chemicals of environmental concern in the ocean Farrington, John W.; Takada, Hideshige (The Oceanography Society, 2014-03)