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dc.contributor.authorRoss, William N.  Concept link
dc.date.accessioned2012-02-22T15:27:01Z
dc.date.available2014-10-22T08:57:24Z
dc.date.issued2012-01
dc.identifier.urihttps://hdl.handle.net/1912/5043
dc.descriptionAuthor Posting. © The Author(s), 2012. This is the author's version of the work. It is posted here by permission of Nature Publishing Group for personal use, not for redistribution. The definitive version was published in Nature Reviews Neuroscience 13 (2012): 157-168, doi:10.1038/nrn3168.en_US
dc.description.abstractAll cells use changes in intracellular calcium concentration [Ca2+]i to regulate cell signaling events In neurons, with their elaborate dendritic and axonal arborizations, there are clear examples of both localized and widespread Ca2+ signals. [Ca2+]i changes generated by Ca2+ entry through voltage gated and ligand gated channels are the best characterised. In addition, [Ca2+]i can increase by release from intracellular stores. These signals have been less studied, in part because they usually are not associated with specific changes in membrane potential. However, recent experiments have revealed dramatic widespread Ca2+ waves and localized spark-like events, particularly in dendrites. Here we review emerging data on the nature of these signals and their functions.en_US
dc.description.sponsorshipSupported by a grant from the National Institutes of Health (NS-16295).en_US
dc.format.mimetypevideo/avi
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dc.format.mimetypeapplication/pdf
dc.language.isoen_USen_US
dc.relation.urihttps://doi.org/10.1038/nrn3168
dc.titleUnderstanding calcium waves and sparks in central neuronsen_US
dc.typePreprinten_US
dc.description.embargo2012-08-01


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