Understanding calcium waves and sparks in central neurons
Ross, William N.
MetadataShow full item record
All cells use changes in intracellular calcium concentration [Ca2+]i to regulate cell signaling events In neurons, with their elaborate dendritic and axonal arborizations, there are clear examples of both localized and widespread Ca2+ signals. [Ca2+]i changes generated by Ca2+ entry through voltage gated and ligand gated channels are the best characterised. In addition, [Ca2+]i can increase by release from intracellular stores. These signals have been less studied, in part because they usually are not associated with specific changes in membrane potential. However, recent experiments have revealed dramatic widespread Ca2+ waves and localized spark-like events, particularly in dendrites. Here we review emerging data on the nature of these signals and their functions.
Author Posting. © The Author(s), 2012. This is the author's version of the work. It is posted here by permission of Nature Publishing Group for personal use, not for redistribution. The definitive version was published in Nature Reviews Neuroscience 13 (2012): 157-168, doi:10.1038/nrn3168.