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    Mechanistic research in aquatic toxicology : perspectives and future directions

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    Hahn_v07.pdf (58.80Kb)
    Date
    2011-05-31
    Author
    Hahn, Mark E.  Concept link
    Metadata
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    Citable URI
    https://hdl.handle.net/1912/4938
    As published
    https://doi.org/10.1016/j.aquatox.2011.06.001
    Abstract
    On the thirtieth anniversary of the journal, I provide a perspective on some of the questions and opportunities for new understanding that will interest aquatic toxicologists during the next thirty years. I focus on mechanisms of toxicity involving transcription factors, signalling pathways, and gene networks involved in toxic and adaptive responses in aquatic animals. Prominent questions address the value of a toxicity pathways approach in aquatic systems, issues involving extrapolation among species, identification of susceptibility genes and useful biomarkers of adverse effect, new emerging contaminants, the importance of epigenetic mechanisms, effects of multiple stressors, evolutionary toxicology, and the relative roles of technical and conceptual limitations to our understanding of chemical effects on aquatic systems.
    Description
    Author Posting. © The Author(s), 2011. This is the author's version of the work. It is posted here by permission of Elsevier B.V. for personal use, not for redistribution. The definitive version was published in Aquatic Toxicology 105 (2011): 67-71, doi:10.1016/j.aquatox.2011.06.001.
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    Suggested Citation
    Preprint: Hahn, Mark E., "Mechanistic research in aquatic toxicology : perspectives and future directions", 2011-05-31, https://doi.org/10.1016/j.aquatox.2011.06.001, https://hdl.handle.net/1912/4938
     
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