Synaptically activated Ca2+ waves and NMDA spikes locally suppress voltage-dependent Ca2+ signalling in rat pyramidal cell dendrites
MetadataShow full item record
Synaptically activated changes in dendritic [Ca2+]i affect many important physiological processes including synaptic plasticity and gene expression. The location, magnitude, and time course of these changes can determine which mechanisms are affected. Therefore, it is important to understand the processes that control and modulate these changes. One important source is Ca2+ entering through voltage gated Ca2+ channels opened by action potentials backpropagating over the dendrites (bAPs). Here we examine how [Ca2+]i changes, caused by regenerative Ca2+ release from internal stores (Ca2+ waves) or by regenerative Ca2+ entry through NMDA receptors (NMDA spikes) affect subsequent bAP evoked [Ca2+]i changes. These large [Ca2+]i increases suppressed the bAP signals in the regions where the preceding [Ca2+]i increases were largest. The suppression was proportional to the magnitude of the large [Ca2+]i change and was insensitive to kinase and phosphatase inhibitors, consistent with suppression due to Ca2+ dependent inhibition of Ca2+ channels.
Author Posting. © The Author(s), 2011. This is the author's version of the work. It is posted here by permission of The Physiological Society for personal use, not for redistribution. The definitive version was published in Journal of Physiology 589 (2011): 4903-4920, doi:10.1113/jphysiol.2011.216564.
Suggested CitationPreprint: Manita, Satoshi, Miyazaki, Kenichi, Ross, William N., "Synaptically activated Ca2+ waves and NMDA spikes locally suppress voltage-dependent Ca2+ signalling in rat pyramidal cell dendrites", 2011-08, https://doi.org/10.1113/jphysiol.2011.216564, https://hdl.handle.net/1912/4859
Showing items related by title, author, creator and subject.
Dendritic signals from rat hippocampal CA1 pyramidal neurons during coincident pre- and post-synaptic activity : a combined voltage- and calcium-imaging study Canepari, Marco; Djurisic, Maja; Zecevic, Dejan (2006-11-16)The non-linear and spatially inhomogeneous interactions of dendritic membrane potential signals that represent the first step in the induction of activity dependent long-term synaptic plasticity are not fully understood, ...
Sodium dynamics in pyramidal neuron dendritic spines : synaptically evoked entry predominantly through AMPA receptors and removal by diffusion Miyazaki, Kenichi; Ross, William N. (Society for Neuroscience, 2017-10-11)Dendritic spines are key elements underlying synaptic integration and cellular plasticity, but many features of these important structures are not known or are controversial. We examined these properties using newly developed ...
Ca2+ sparks and puffs are generated and interact in rat hippocampal CA1 pyramidal neuron dendrites Miyazaki, Kenichi; Ross, William N. (Society for Neuroscience, 2013-11-06)1,4,5-Inositol trisphosphate receptors (IP3Rs) and ryanodine receptors (RyRs) mediate release of Ca2+ from internal stores in many neurons. The details of the spatial and temporal characteristics of these signals and their ...