Synaptically activated Ca2+ waves and NMDA spikes locally suppress voltage-dependent Ca2+ signalling in rat pyramidal cell dendrites
Date
2011-08Metadata
Show full item recordCitable URI
https://hdl.handle.net/1912/4859As published
https://doi.org/10.1113/jphysiol.2011.216564Keyword
Dendrite; Calcium; Pyramidal neuronAbstract
Synaptically activated changes in dendritic [Ca2+]i affect many
important physiological processes including synaptic plasticity and gene expression. The
location, magnitude, and time course of these changes can determine which mechanisms
are affected. Therefore, it is important to understand the processes that control and
modulate these changes. One important source is Ca2+ entering through voltage gated
Ca2+ channels opened by action potentials backpropagating over the dendrites (bAPs).
Here we examine how [Ca2+]i changes, caused by regenerative Ca2+ release from internal
stores (Ca2+ waves) or by regenerative Ca2+ entry through NMDA receptors (NMDA
spikes) affect subsequent bAP evoked [Ca2+]i changes. These large [Ca2+]i increases
suppressed the bAP signals in the regions where the preceding [Ca2+]i increases were
largest. The suppression was proportional to the magnitude of the large [Ca2+]i change
and was insensitive to kinase and phosphatase inhibitors, consistent with suppression due
to Ca2+ dependent inhibition of Ca2+ channels.
Description
Author Posting. © The Author(s), 2011. This is the author's version of the work. It is posted here by permission of The Physiological Society for personal use, not for redistribution. The definitive version was published in Journal of Physiology 589 (2011): 4903-4920, doi:10.1113/jphysiol.2011.216564.
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Suggested Citation
Preprint: Manita, Satoshi, Miyazaki, Kenichi, Ross, William N., "Synaptically activated Ca2+ waves and NMDA spikes locally suppress voltage-dependent Ca2+ signalling in rat pyramidal cell dendrites", 2011-08, https://doi.org/10.1113/jphysiol.2011.216564, https://hdl.handle.net/1912/4859Related items
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