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    Target repurposing for neglected diseases

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    Pollastri_Campbell_Target_Repurposing_Revision_FINAL.pdf (168.0Kb)
    Date
    2011-06-30
    Author
    Pollastri, Michael P.  Concept link
    Campbell, Robert K.  Concept link
    Metadata
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    Citable URI
    https://hdl.handle.net/1912/4824
    As published
    https://doi.org/10.4155/fmc.11.92
    Abstract
    Infectious diseases are an enormous burden to global health, and since drug discovery is costly, those infectious diseases that affect the developing world are often not pursued by commercial drug discovery efforts. Therefore, pragmatic means by which new therapeutics can be discovered are needed. One such approach is target repurposing, where pathogen targets are matched with homologous human targets that have been pursued for drug discovery for other indications. In many cases, the medicinal chemistry, structural biology, and biochemistry knowledge around these human targets can be directly repurposed to launch and accelerate new drug discovery efforts against the pathogen targets. This article describes the overarching strategy of target repurposing as a tool for initiating and prosecuting neglected disease drug discovery programs, highlighting this approach with three case studies.
    Description
    Author Posting. © The Author(s), 2011. This is the author's version of the work. It is posted here by permission of Future Science for personal use, not for redistribution. The definitive version was published in Future Medicinal Chemistry 3 (2011): 1307-1315, doi:10.4155/fmc.11.92.
    Collections
    • Josephine Bay Paul Center in Comparative Molecular Biology and Evolution
    Suggested Citation
    Preprint: Pollastri, Michael P., Campbell, Robert K., "Target repurposing for neglected diseases", 2011-06-30, https://doi.org/10.4155/fmc.11.92, https://hdl.handle.net/1912/4824
     
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