Now showing items 1-3 of 3

  • Acute increase of α-synuclein inhibits synaptic vesicle recycling evoked during intense stimulation 

    Busch, David J.; Oliphint, Paul A.; Walsh, Rylie B.; Banks, Susan M. L.; Woods, Wendy S.; George, Julia M.; Morgan, Jennifer R. (American Society for Cell Biology, 2014-10-01)
    Parkinson's disease is associated with multiplication of the α-synuclein gene and abnormal accumulation of the protein. In animal models, α-synuclein overexpression broadly impairs synaptic vesicle trafficking. However, ...
  • Regeneration in the era of functional genomics and gene network analysis 

    Smith, Joel; Morgan, Jennifer R.; Zottoli, Steven J.; Smith, Peter J. S.; Buxbaum, Joseph D.; Bloom, Ona E. (Marine Biological Laboratory, 2011-08)
    What gives an organism the ability to regrow tissues and to recover function where another organism fails is the central problem of regenerative biology. The challenge is to describe the mechanisms of regeneration at the ...
  • A role for an Hsp70 nucleotide exchange factor in the regulation of synaptic vesicle endocytosis 

    Morgan, Jennifer R.; Jiang, Jianwen; Oliphint, Paul A.; Jin, Suping; Gimenez, Luis E.; Busch, David J.; Foldes, Andrea E.; Zhuo, Yue; Sousa, Rui; Lafer, Eileen M. (Society for Neuroscience, 2013-05-01)
    Neurotransmission requires a continuously available pool of synaptic vesicles (SVs) that can fuse with the plasma membrane and release their neurotransmitter contents upon stimulation. After fusion, SV membranes and membrane ...