Now showing items 36-47 of 47

    • Regeneration in the era of functional genomics and gene network analysis 

      Smith, Joel; Morgan, Jennifer R.; Zottoli, Steven J.; Smith, Peter J. S.; Buxbaum, Joseph D.; Bloom, Ona E. (Marine Biological Laboratory, 2011-08)
      What gives an organism the ability to regrow tissues and to recover function where another organism fails is the central problem of regenerative biology. The challenge is to describe the mechanisms of regeneration at the ...
    • Regeneration, stem cells, and aging in the tunicate Ciona : insights from the oral siphon 

      Jeffery, William R. (2015-04)
      Regeneration studies in the tunicate Ciona intestinalis have recently been focused on the potential of adult stem cells to replace injured tissues and organs during the adult life cycle using the oral siphon (OS) as a ...
    • A role for an Hsp70 nucleotide exchange factor in the regulation of synaptic vesicle endocytosis 

      Morgan, Jennifer R.; Jiang, Jianwen; Oliphint, Paul A.; Jin, Suping; Gimenez, Luis E.; Busch, David J.; Foldes, Andrea E.; Zhuo, Yue; Sousa, Rui; Lafer, Eileen M. (Society for Neuroscience, 2013-05-01)
      Neurotransmission requires a continuously available pool of synaptic vesicles (SVs) that can fuse with the plasma membrane and release their neurotransmitter contents upon stimulation. After fusion, SV membranes and membrane ...
    • Spatial manipulation of cells and organelles using single electrode dielectrophoresis 

      Graham, David M.; Messerli, Mark A.; Pethig, Ronald (Informa Healthcare USA, 2012-01)
      The selection, isolation, and accurate positioning of single cells in three dimensions are increasingly desirable in many areas of cell biology and tissue engineering. We describe the application of a simple and low cost ...
    • Suction-based propulsion as a basis for efficient animal swimming 

      Gemmell, Brad J.; Colin, Sean P.; Costello, John H.; Dabiri, John O. (Nature Publishing Group, 2015-11-03)
      A central and long-standing tenet in the conceptualization of animal swimming is the idea that propulsive thrust is generated by pushing the surrounding water rearward. Inherent in this perspective is the assumption that ...
    • Target detection in insects : optical, neural and behavioral optimizations 

      Gonzalez-Bellido, Paloma T.; Fabian, Samuel T.; Nordstrom, Karin (Elsevier, 2016-09-20)
      Motion vision provides important cues for many tasks. Flying insects, for example, may pursue small, fast moving targets for mating or feeding purposes, even when these are detected against self-generated optic flow. Since ...
    • Trade-off between transcriptome plasticity and genome evolution in cephalopods 

      Liscovitch-Brauer, Noa; Alon, Shahar; Porath, Hagit T.; Elstein, Boaz; Unger, Ron; Ziv, Tamar; Admon, Arie; Levanon, Erez; Rosenthal, Joshua J. C.; Eisenberg, Eli (2017-03)
      RNA editing, a post-transcriptional process, allows the diversification of proteomes beyond the genomic blueprint; however it is infrequently used among animals. Recent reports suggesting increased levels of RNA editing ...
    • Transcriptomic insights into genetic diversity of protein-coding genes in X. laevis 

      Savova, Virginia; Pearl, Esther J.; Boke, Elvan; Nag, Anwesha; Adzhubei, Ivan; Horb, Marko E.; Peshkin, Leonid (2017-03)
      We characterize the genetic diversity of Xenopus laevis strains using RNA-seq data and allele- specific analysis. This data provides a catalogue of coding variation, which can be used for improving the genomic sequence, ...
    • Transient expression of Ngn3 in Xenopus endoderm promotes early and ectopic development of pancreatic beta and delta cells 

      Oropeza, Daniel; Horb, Marko E. (2011-11)
      Promoting ectopic development of pancreatic beta cells from other cell types is one of the strategies being pursued for the treatment of diabetes. To achieve this, a detailed outline of the molecular lineage that operates ...
    • The tunicate Ciona : a model system for understanding the relationship between regeneration and aging 

      Jeffery, William R. (Taylor & Francis, 2014-06-10)
      The use of the tunicate Ciona intestinalis as a model system to study the relationship between regeneration and aging is reviewed. Ciona has powerful regeneration capacities, which fade with age. Some additional benefits ...
    • Xenopus as a model for GI/pancreas disease 

      Salanga, Matthew C.; Horb, Marko E. (2015-03)
      Diseases affecting endodermal organs like the pancreas, lung and gastrointestinal (GI) tract have a substantial impact on human welfare. Since many of these are congenital defects that arise as a result of defects during ...
    • Xenopus staufen2 is required for anterior endodermal organ formation 

      Bilogan, Cassandra K.; Horb, Marko E. (2011-11)
      Defining the regulatory molecular networks involved in patterning the developing anterior endoderm is essential to understanding how the pancreas, liver, stomach and duodenum are discretely specified from each other. In ...