Recent Submissions

  • Swimming kinematics and performance of spinal transected lampreys with different levels of axon regeneration 

    Fies, Jacob; Gemmell, Brad J.; Fogerson, Stephanie M.; Morgan, Jennifer R.; Tytell, Eric D.; Colin, Sean P. (The Company of Biologists, 2021-11-05)
    Axon regeneration is critical for restoring neural function after spinal cord injury. This has prompted a series of studies on the neural and functional recovery of lampreys after spinal cord transection. Despite this, ...
  • Deep learning is widely applicable to phenotyping embryonic development and disease 

    Naert, Thomas; Çiçek, Özgün; Ogar, Paulina; Bürgi, Max; Shaidani, Nikko-Ideen; Kaminski, Michael M.; Xu, Yuxiao; Grand, Kelli; Vujanovic, Marko; Prata, Daniel; Hildebrandt, Friedhelm; Brox, Thomas; Ronneberger, Olaf; Voigt, Fabian F.; Helmchen, Fritjof; Loffing, Johannes; Horb, Marko E.; Rankin Willsey, Helen; Lienkamp, Soeren S. (The Company of Biologists, 2021-11-05)
    Genome editing simplifies the generation of new animal models for congenital disorders. However, the detailed and unbiased phenotypic assessment of altered embryonic development remains a challenge. Here, we explore how ...
  • The Nereid on the rise: Platynereis as a model system 

    Ozpolat, B. Duygu; Randel, Nadine; Williams, Elizabeth A.; Bezares-Calderón, Luis Alberto; Andreatta, Gabriele; Balavoine, Guillaume; Bertucci, Paola Y.; Ferrier, David E. K.; Gambi, Maria Cristina; Gazave, Eve; Handberg-Thorsager, Mette; Hardege, Jörg; Hird, Cameron; Hsieh, Yu-Wen; Hui, Jerome; Mutemi, Kevin Nzumbi; Schneider, Stephan Q.; Simakov, Oleg; Vergara, Hernando M.; Vervoort, Michel; Jékely, Gáspár; Tessmar-Raible, Kristin; Raible, Florian; Arendt, Detlev (BMC, 2021-09-27)
    The Nereid Platynereis dumerilii (Audouin and Milne Edwards (Annales des Sciences Naturelles 1:195–269, 1833) is a marine annelid that belongs to the Nereididae, a family of errant polychaete worms. The Nereid shows a ...
  • Explaining regeneration: cells and limbs as complex living systems, learning from history 

    MacCord, Kate; Maienschein, Jane (Frontiers Media, 2021-08-31)
    Regeneration has been investigated since Aristotle, giving rise to many ways of explaining what this process is and how it works. Current research focuses on gene expression and cell signaling of regeneration within ...
  • Real-time polarization microscopy of fibrillar collagen in histopathology 

    Keikhosravi, Adib; Shribak, Michael; Conklin, Matthew W.; Liu, Yuming; Li, Bin; Loeffler, Agnes; Levenson, Richard; Eliceiri, Kevin (Nature Research, 2021-09-24)
    Over the past two decades, fibrillar collagen reorganization parameters such as the amount of collagen deposition, fiber angle and alignment have been widely explored in numerous studies. These parameters are now widely ...
  • Corals regulate the distribution and abundance of Symbiodiniaceae and biomolecules in response to changing water depth and sea surface temperature 

    Sivaguru, Mayandi; Todorov, Lauren G.; Fouke, Courtney E.; Munro, Cara M. O.; Fouke, Kyle W.; Fouke, Kaitlyn E.; Baughman, Melinda E.; Fouke, Bruce W. (Nature Research, 2021-01-26)
    The Scleractinian corals Orbicella annularis and O. faveolata have survived by acclimatizing to environmental changes in water depth and sea surface temperature (SST). However, the complex physiological mechanisms by which ...
  • Intranuclear birefringent inclusions in paraffin sections by polychromatic polarization microscopy 

    Vitkunaite, Aiste; Laurinaviciene, Aida; Plancoulaine, Benoit; Rasmusson, Allan; Levenson, Richard; Shribak, Michael; Laurinavicius, Arvydas (Nature Research, 2021-03-18)
    Intranuclear birefringent inclusions (IBI) found in various cell types in paraffin-embedded tissue sections have long been considered to be a tissue processing artifact, although an association with biological processes ...
  • Oxygen supply capacity breathes new life into critical oxygen partial pressure (Pcrit) 

    Seibel, Brad A.; Andres, Alyssa; Birk, Matthew A.; Burns, Alexandra L.; Shaw, C. Tracy; Timpe, Alexander W.; Welsh, Christina J. (The Company of Biologists, 2021-04-30)
    The critical oxygen partial pressure (Pcrit), typically defined as the PO2 below which an animal's metabolic rate (MR) is unsustainable, is widely interpreted as a measure of hypoxia tolerance. Here, Pcrit is defined as ...
  • Postnatal structural development of mammalian basilar membrane provides anatomical basis for the maturation of tonotopic maps and frequency tuning 

    Tani, Tomomi; Koike-Tani, Maki; Tran, Mai Thi; Shribak, Michael; Levic, Snezana (Nature Research, 2021-04-07)
    The basilar membrane (BM) of the mammalian cochlea constitutes a spiraling acellular ribbon that is intimately attached to the organ of Corti. Its graded stiffness, increasing from apex to the base of the cochlea provides ...
  • Effects of excess brain-derived human alpha-synuclein on synaptic vesicle trafficking 

    Román-Vendrell, Cristina; Medeiros, Audrey T.; Sanderson, John B.; Jiang, Haiyang; Bartels, Tim; Morgan, Jennifer R. (Frontiers Media, 2021-02-04)
    α-Synuclein is a presynaptic protein that regulates synaptic vesicle trafficking under physiological conditions. However, in several neurodegenerative diseases, including Parkinson’s disease, dementia with Lewy bodies, and ...
  • New species can broaden myelin research: suitability of little skate, Leucoraja erinacea 

    Möbius, Wiebke; Hümmert, Sophie; Ruhwedel, Torben; Kuzirian, Alan M.; Gould, Robert M. (MDPI, 2021-02-11)
    Although myelinated nervous systems are shared among 60,000 jawed vertebrates, studies aimed at understanding myelination have focused more and more on mice and zebrafish. To obtain a broader understanding of the myelination ...
  • Small-molecule mimicry hunting strategy in the imperial cone snail, Conus imperialis 

    Torres, Joshua P.; Lin, Zhenjian; Watkins, Maren; Salcedo, Paula Flórez; Baskin, Robert P.; Elhabian, Shireen; Safavi-Hemami, Helena; Taylor, Dylan; Tun, Jortan; Concepcion, Gisela P.; Saguil, Noel; Yanagihara, Angel A.; Fang, Yixin; McArthur, Jeffrey R.; Tae, Han-Shen; Finol-Urdaneta, Rocio K.; Ozpolat, B. Duygu; Olivera, Baldomero M.; Schmidt, Eric W. (American Association for the Advancement of Science, 2021-03-12)
    Venomous animals hunt using bioactive peptides, but relatively little is known about venom small molecules and the resulting complex hunting behaviors. Here, we explored the specialized metabolites from the venom of the ...
  • Dynamic organization of cortical actin filaments during the ooplasmic segregation of ascidian Ciona eggs 

    Ishii, Hirokazu; Tani, Tomomi (American Society for Cell Biology, 2021-01-28)
    Spatial reorganization of cytoplasm in zygotic cells is critically important for establishing the body plans of many animal species. In ascidian zygotes, maternal determinants (mRNAs) are first transported to the vegetal ...
  • Chaperone proteins as ameliorators of alpha-synuclein-induced synaptic pathologies: Insights into Parkinson's disease 

    Banks, Susan M. L.; Medeiros, Audrey T.; Sousa, Rui; Lafer, Eileen M.; Morgan, Jennifer R. (Medknow Publications, 2020-11-27)
    α-Synuclein accumulation causes synaptic vesicle trafficking defects and may underlie neurodegenerative disorders: Neurodegenerative disorders, such as Parkinson’s disease (PD) and other synucleinopathies, impact the lives ...
  • Recovery of burrowing behavior after spinal cord injury in the larval sea lamprey 

    Katz, Hilary R.; Fouke, Kaitlyn E.; Losurdo, Nicole A.; Morgan, Jennifer R. (University of Chicago Press, 2020-10-27)
    Following traumatic spinal cord injury, most mammalian species are unable to achieve substantial neuronal regeneration and often experience loss of locomotor function. In contrast, larval sea lampreys (Petromyzon marinus) ...
  • A frog with three sex chromosomes that co-mingle together in nature: Xenopus tropicalis has a degenerate W and a Y that evolved from a Z chromosome 

    Furman, Benjamin L. S.; Cauret, Caroline M. S.; Knytl, Martin; Song, Xue-Ying; Premachandra, Tharindu; Ofori-Boateng, Caleb; Jordan, Danielle C.; Horb, Marko E.; Evans, Ben J. (Public Library of Science, 2020-11-09)
    In many species, sexual differentiation is a vital prelude to reproduction, and disruption of this process can have severe fitness effects, including sterility. It is thus interesting that genetic systems governing sexual ...
  • The role of suction thrust in the metachronal paddles of swimming invertebrates 

    Colin, Sean P.; Costello, John H.; Sutherland, Kelly R.; Gemmell, Brad J.; Dabiri, John O.; Du Clos, Kevin T. (Nature Research, 2020-10-20)
    An abundance of swimming animals have converged upon a common swimming strategy using multiple propulsors coordinated as metachronal waves. The shared kinematics suggest that even morphologically and systematically diverse ...
  • Sox17 and ß-catenin co-occupy Wnt-responsive enhancers to govern the endoderm gene regulatory network 

    Mukherjee, Shreyasi; Chaturvedi, Praneet; Rankin, Scott A.; Fish, Margaret B.; Wlizla, Marcin; Paraiso, Kitt D.; MacDonald, Melissa; Chen, Xiaoting; Weirauch, Matthew T.; Blitz, Ira L.; Cho, Ken W. Y.; Zorn, Aaron M. (eLife Sciences Publications, 2020-09-07)
    Lineage specification is governed by gene regulatory networks (GRNs) that integrate the activity of signaling effectors and transcription factors (TFs) on enhancers. Sox17 is a key transcriptional regulator of definitive ...
  • CRISPR/Cas9 mediated mutation of the mtnr1a melatonin receptor gene causes rod photoreceptor degeneration in developing Xenopus tropicalis 

    Wiechmann, Allan F.; Martin, Teryn A.; Horb, Marko E. (Nature Research, 2020-08-13)
    Nighttime surges in melatonin levels activate melatonin receptors, which synchronize cellular activities with the natural light/dark cycle. Melatonin receptors are expressed in several cell types in the retina, including ...
  • Maximizing CRISPR/Cas9 phenotype penetrance applying predictive modeling of editing outcomes in Xenopus and zebrafish embryos 

    Naert, Thomas; Tulkens, Dieter; Edwards, Nicole A.; Carron, Marjolein; Shaidani, Nikko-Ideen; Wlizla, Marcin; Boel, Annekatrien; Demuynck, Suzan; Horb, Marko E.; Coucke, Paul; Willaert, Andy; Zorn, Aaron M.; Vleminckx, Kris (Nature Research, 2020-09-04)
    CRISPR/Cas9 genome editing has revolutionized functional genomics in vertebrates. However, CRISPR/Cas9 edited F0 animals too often demonstrate variable phenotypic penetrance due to the mosaic nature of editing outcomes ...

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