Now showing items 1-20 of 108

    • The role of suction thrust in the metachronal paddles of swimming invertebrates 

      Colin, Sean P.; Costello, John H.; Sutherland, Kelly R.; Gemmell, Brad J.; Dabiri, John O.; Du Clos, Kevin T. (Nature Research, 2020-10-20)
      An abundance of swimming animals have converged upon a common swimming strategy using multiple propulsors coordinated as metachronal waves. The shared kinematics suggest that even morphologically and systematically diverse ...
    • Sox17 and ß-catenin co-occupy Wnt-responsive enhancers to govern the endoderm gene regulatory network 

      Mukherjee, Shreyasi; Chaturvedi, Praneet; Rankin, Scott A.; Fish, Margaret B.; Wlizla, Marcin; Paraiso, Kitt D.; MacDonald, Melissa; Chen, Xiaoting; Weirauch, Matthew T.; Blitz, Ira L.; Cho, Ken W. Y.; Zorn, Aaron M. (eLife Sciences Publications, 2020-09-07)
      Lineage specification is governed by gene regulatory networks (GRNs) that integrate the activity of signaling effectors and transcription factors (TFs) on enhancers. Sox17 is a key transcriptional regulator of definitive ...
    • CRISPR/Cas9 mediated mutation of the mtnr1a melatonin receptor gene causes rod photoreceptor degeneration in developing Xenopus tropicalis 

      Wiechmann, Allan F.; Martin, Teryn A.; Horb, Marko E. (Nature Research, 2020-08-13)
      Nighttime surges in melatonin levels activate melatonin receptors, which synchronize cellular activities with the natural light/dark cycle. Melatonin receptors are expressed in several cell types in the retina, including ...
    • Maximizing CRISPR/Cas9 phenotype penetrance applying predictive modeling of editing outcomes in Xenopus and zebrafish embryos 

      Naert, Thomas; Tulkens, Dieter; Edwards, Nicole A.; Carron, Marjolein; Shaidani, Nikko-Ideen; Wlizla, Marcin; Boel, Annekatrien; Demuynck, Suzan; Horb, Marko E.; Coucke, Paul; Willaert, Andy; Zorn, Aaron M.; Vleminckx, Kris (Nature Research, 2020-09-04)
      CRISPR/Cas9 genome editing has revolutionized functional genomics in vertebrates. However, CRISPR/Cas9 edited F0 animals too often demonstrate variable phenotypic penetrance due to the mosaic nature of editing outcomes ...
    • α-Synuclein-112 impairs synaptic vesicle recycling consistent with its enhanced membrane binding properties 

      Soll, Lindsey G.; Eisen, Julia N.; Vargas, Karina J.; Medeiros, Audrey T.; Hammar, Katherine M.; Morgan, Jennifer R. (Frontiers Media, 2020-05-29)
      Synucleinopathies are neurological disorders associated with α-synuclein overexpression and aggregation. While it is well-established that overexpression of wild type α-synuclein (α-syn-140) leads to cellular toxicity and ...
    • Long-term imaging of the photosensitive, reef-building coral Acropora muricata using light-sheet illumination 

      Laissue, Pierre Philippe; Roberson, Loretta M.; Gu, Yan; Qian, Chen; Smith, David J. (Nature Research, 2020-06-25)
      Coral reefs are in alarming decline due to climate emergency, pollution and other man-made disturbances. The numerous ecosystem services derived from coral reefs are underpinned by the growth and physical complexity of ...
    • The effect of bacteria on planula-larvae settlement and metamorphosis in the octocoral Rhytisma fulvum fulvum 

      Freire, Isabel; Gutner-Hoch, Eldad; Muras, Andrea; Benayahu, Yehuda; Otero, Ana (Public Library of Science, 2019-09-30)
      While increasing evidence supports a key role of bacteria in coral larvae settlement and development, the relative importance of environmentally-acquired versus vertically-transferred bacterial population is not clear. ...
    • Wound healing across the animal kingdom: Crosstalk between the immune system and the extracellular matrix 

      Arenas Gómez, Claudia Marcela; Sabin, Keith Z.; Echeverri, Karen (Wiley, 2020-04-20)
      Tissue regeneration is widespread in the animal kingdom. To date, key roles for different molecular and cellular programs in regeneration have been described, but the ultimate blueprint for this talent remains elusive. In ...
    • Radial alignment of microtubules through tubulin polymerization in an evaporating droplet 

      Keya, Jakia Jannat; Kudoh, Hiroki; Kabir, Arif Md. Rashedul; Inoue, Daisuke; Miyamoto, Nobuyoshi; Tani, Tomomi; Kakugo, Akira; Shikinaka, Kazuhiro (Public Library of Science, 2020-04-10)
      We report the formation of spherulites from droplets of highly concentrated tubulin solution via nucleation and subsequent polymerization to microtubules (MTs) under water evaporation by heating. Radial alignment of MTs ...
    • Spatially regulated editing of genetic information within a neuron 

      Vallecillo-Viejo, Isabel C.; Liscovitch-Brauer, Noa; Diaz Quiroz, Juan F.; Montiel-González, Maria Fernanda; Nemes, Sonya E.; Rangan, Kavita J.; Levinson, Simon R.; Eisenberg, Eli; Rosenthal, Joshua J. C. (Oxford University Press, 2020-03-23)
      In eukaryotic cells, with the exception of the specialized genomes of mitochondria and plastids, all genetic information is sequestered within the nucleus. This arrangement imposes constraints on how the information can ...
    • FXR1 splicing is important for muscle development and biomolecular condensates in muscle cells 

      Smith, Jean A.; Curry, Ennessa G.; Blue, R. Eric; Roden, Christine; Dundon, Samantha E.R.; Rodríguez-Vargas, Anthony; Jordan, Danielle C.; Chen, Xiaomin; Lyons, Shawn M.; Crutchley, John M.; Anderson, Paul; Horb, Marko E.; Gladfelter, Amy S.; Giudice, Jimena (Rockefeller University Press, 2020-03-13)
      Fragile-X mental retardation autosomal homologue-1 (FXR1) is a muscle-enriched RNA-binding protein. FXR1 depletion is perinatally lethal in mice, Xenopus, and zebrafish; however, the mechanisms driving these phenotypes ...
    • A de novo reference transcriptome for Bolitoglossa vallecula, an Andean mountain salamander in Colombia 

      Arenas Gómez, Claudia Marcela; Woodcock, M. Ryan; Smith, Jeramiah J.; Voss, S. Randal; Delgado, Jean Paul (Elsevier, 2020-02-11)
      The amphibian order Caudata, contains several important model species for biological research. However, there is need to generate transcriptome data from representative species of the primary salamander families. Here we ...
    • 12-h clock regulation of genetic information flow by XBP1s 

      Pan, Yinghong; Ballance, Heather; Meng, Huan; Gonzalez, Naomi; Kim, Sam-Moon; Abdurehman, Leymaan; York, Brian; Chen, Xi; Schnytzer, Yisrael; Levy, Oren; Dacso, Clifford C.; McClung, Colleen A.; O’Malley, Bert W.; Liu, Silvia; Zhu, Bokai (Public Library of Science, 2020-01-14)
      Our group recently characterized a cell-autonomous mammalian 12-h clock independent from the circadian clock, but its function and mechanism of regulation remain poorly understood. Here, we show that in mouse liver, ...
    • The various routes to functional regeneration in the central nervous system 

      Echeverri, Karen (Nature Research, 2020-01-29)
      The axolotl is a type of Mexican salamander with astonishing regenerative capacity1. In our recent paper, we identified a signaling heterodimer that is formed directly after injury in the glial cells adjacent to the injury ...
    • A draft genome sequence of the elusive giant squid, Architeuthis dux 

      da Fonseca, Rute R.; Couto, Alvarina; Machado, Andre M.; Brejova, Brona; Albertin, Carolin B.; Silva, Filipe; Gardner, Paul; Baril, Tobias; Hayward, Alex; Campos, Alexandre; Ribeiro, Ângela M.; Barrio-Hernandez, Inigo; Hoving, Henk-Jan; Tafur-Jimenez, Ricardo; Chu, Chong; Frazão, Barbara; Petersen, Bent; Peñaloza, Fernando; Musacchia, Francesco; Alexander, Graham C., Jr.; Osório, Hugo; Winkelmann, Inger; Simakov, Oleg; Rasmussen, Simon; Rahman, M. Ziaur; Pisani, Davide; Vinther, Jakob; Jarvis, Erich; Zhang, Guojie; Strugnell, Jan M.; Castro, L. Filipe C.; Fedrigo, Olivier; Patricio, Mateus; Li, Qiye; Rocha, Sara; Antunes, Agostinho; Wu, Yufeng; Ma, Bin; Sanges, Remo; Vinar, Tomas; Blagoev, Blagoy; Sicheritz-Ponten, Thomas; Nielsen, Rasmus; Gilbert, M. Thomas P. (Oxford University Press, 2020-01-16)
      Background: The giant squid (Architeuthis dux; Steenstrup, 1857) is an enigmatic giant mollusc with a circumglobal distribution in the deep ocean, except in the high Arctic and Antarctic waters. The elusiveness of the ...
    • Hsc70 ameliorates the vesicle recycling defects caused by excess alpha-synuclein at synapses 

      Banks, Susan M. L.; Medeiros, Audrey T.; McQuillan, Molly; Busch, David J.; Ibarraran-Viniegra, Ana Sofia; Sousa, Rui; Lafer, Eileen M.; Morgan, Jennifer R. (Society for Neuroscience, 2020-01-15)
      α-Synuclein overexpression and aggregation are linked to Parkinson’s disease (PD), dementia with Lewy bodies (DLB), and several other neurodegenerative disorders. In addition to effects in the cell body, α-synuclein ...
    • Specialization for rapid excitation in fast squid tentacle muscle involves action potentials absent in slow arm muscle 

      Gilly, William; Renken, Corbin; Rosenthal, Joshua J. C.; Kier, William M. (Company of Biologists, 2020-01-03)
      An important aspect of the performance of many fast muscle fiber types is rapid excitation. Previous research on the cross-striated muscle fibers responsible for the rapid tentacle strike in squid has revealed the ...
    • A scalable culturing system for the marine annelid Platynereis dumerilii 

      Kuehn, Emily; Stockinger, Alexander W.; Girard, Jerome; Raible, Florian; Ozpolat, B. Duygu (Public Library of Science, 2019-12-05)
      Platynereis dumerilii is a marine segmented worm (annelid) with externally fertilized embryos and it can be cultured for the full life cycle in the laboratory. The accessibility of embryos and larvae combined with the ...
    • Thrust generation during steady swimming and acceleration from rest in anguilliform swimmers 

      Du Clos, Kevin T.; Dabiri, John O.; Costello, John H.; Colin, Sean P.; Morgan, Jennifer R.; Fogerson, Stephanie M.; Gemmell, Brad J. (Company of Biologists, 2019-11-18)
      Escape swimming is a crucial behavior by which undulatory swimmers evade potential threats. The hydrodynamics of escape swimming have not been well studied, particularly for anguilliform swimmers, such as the sea lamprey ...
    • Coupled genomic evolutionary histories as signatures of organismal innovations in cephalopods: co-evolutionary signatures across levels of genome organization may shed light on functional linkage and origin of cephalopod novelties 

      Ritschard, Elena A.; Whitelaw, Brooke; Albertin, Caroline B.; Cooke, Ira R.; Strugnell, Jan M.; Simakov, Oleg (Wiley, 2019-10-30)
      How genomic innovation translates into organismal organization remains largely unanswered. Possessing the largest invertebrate nervous system, in conjunction with many species‐specific organs, coleoid cephalopods (octopuses, ...