Now showing items 1-20 of 141

    • Spinal cord regeneration—the origins of progenitor cells for functional rebuilding 

      Walker, Sarah E.; Echeverri, Karen (Elsevier, 2022-05-24)
      The spinal cord is one of the most important structures for all vertebrate animals as it connects almost all parts of the body to the brain. Injury to the mammalian spinal cord has devastating consequences, resulting in ...
    • Identification of LINE retrotransposons and long non-coding RNAs expressed in the octopus brain 

      Petrosino, Giuseppe; Ponte, Giovanna; Volpe, Massimiliano; Zarrella, Ilaria; Ansaloni, Federico; Langella, Concetta; Di Cristina, Giulia; Finaurini, Sara; Russo, Monia T.; Basu, Swaraj; Musacchia, Francesco; Ristoratore, Filomena; Pavlinic, Dinko; Benes, Vladimir; Ferrante, Maria I.; Albertin, Carolin B.; Simakov, Oleg; Gustincich, Stefano; Sanges, Remo (BMC, 2022-05-18)
      Background Transposable elements (TEs) widely contribute to the evolution of genomes allowing genomic innovations, generating germinal and somatic heterogeneity, and giving birth to long non-coding RNAs (lncRNAs). These ...
    • Endogenous retroviruses augment amphibian (Xenopus laevis) tadpole antiviral protection 

      Kalia, Namarta; Hauser, Kelsey A.; Burton, Sarah; Hossainey, Muhammad Riadul Haque; Zelle, Mira; Horb, Marko E.; Grayfer, Leon (American Society for Microbiology, 2022-05-16)
      The global amphibian declines are compounded by infections with members of the Ranavirus genus such as Frog Virus 3 (FV3). Premetamorphic anuran amphibians are believed to be significantly more susceptible to FV3 while ...
    • Genome and transcriptome mechanisms driving cephalopod evolution 

      Albertin, Carolin B.; Medina-Ruiz, Sofia; Mitros, Therese; Schmidbaur, Hannah; Sanchez, Gustavo; Wang, Z. Yan; Grimwood, Jane; Rosenthal, Joshua J. C.; Ragsdale, Clifton W.; Simakov, Oleg; Rokhsar, Daniel S. (Nature Research, 2022-05-04)
      Cephalopods are known for their large nervous systems, complex behaviors and morphological innovations. To investigate the genomic underpinnings of these features, we assembled the chromosomes of the Boston market squid, ...
    • Emergence of novel cephalopod gene regulation and expression through large-scale genome reorganization 

      Schmidbaur, Hannah; Kawaguchi, Akane; Clarence, Tereza; Fu, Xiao; Hoang, Oi Pui; Zimmermann, Bob; Ritschard, Elena A.; Weissenbacher, Anton; Foster, Jamie S.; Nyholm, Spencer V.; Bates, Paul A.; Albertin, Carolin B.; Tanaka, Elly; Simakov, Oleg (Nature Research, 2022-04-21)
      Coleoid cephalopods (squid, cuttlefish, octopus) have the largest nervous system among invertebrates that together with many lineage-specific morphological traits enables complex behaviors. The genomic basis underlying ...
    • Activating transcription factor 3 (ATF3) is a highly conserved pro-regenerative transcription factor in the vertebrate nervous system 

      Katz, Hilary R.; Arcese, Anthony A.; Bloom, Ona E.; Morgan, Jennifer R. (Frontiers Media, 2022-03-08)
      The vertebrate nervous system exhibits dramatic variability in regenerative capacity across species and neuronal populations. For example, while the mammalian central nervous system (CNS) is limited in its regenerative ...
    • Advances in genome editing tools 

      Horb, Marko E.; Abu-Daya, Anita; Wlizla, Marcin; Noble, Anna; Guille, Matthew (Taylor & Francis, 2022-04-19)
      This book focuses on the amphibian, Xenopus, one of the most commonly used model animals in the biological sciences. Over the past 50 years, the use of Xenopus has made possible many fundamental contributions to our knowledge ...
    • Modulation of G(q)/PLC-mediated signaling by acute lithium exposure 

      Sánchez Triviño, Cesar Adolfo; Landinez, Maria Paula; Duran, Sara; Gomez, Maria del Pilar; Nasi, Enrico (Frontiers Media, 2022-02-15)
      Although lithium has long been one of the most widely used pharmacological agents in psychiatry, its mechanisms of action at the cellular and molecular levels remain poorly understood. One of the targets of Li+ is the ...
    • Regulation of stem cell identity by miR-200a during spinal cord regeneration 

      Walker, Sarah E.; Sabin, Keith Z.; Gearhart, Micah D.; Yamamoto, Kenta (Company of Biologists, 2022-02-14)
      Axolotls are an important model organism for multiple types of regeneration, including functional spinal cord regeneration. Remarkably, axolotls can repair their spinal cord after a small lesion injury and can also regenerate ...
    • Pupil dilation and constriction in the skate Leucoraja erinacea in a simulated natural light field 

      Mäthger, Lydia M.; Bok, Michael J.; Liebich, Jan; Sicius, Lucia; Nilsson, Dan-Eric (The Company of Biologists, 2022-02-14)
      The skate Leucoraja erinacea has an elaborately shaped pupil, whose characteristics and functions have received little attention. The goal of our study was to investigate the pupil response in relation to natural ambient ...
    • Ramisyllis kingghidorahi n. Sp., a new branching annelid from Japan 

      Aguado, M. Teresa; Ponz-Segrelles, Guillermo; Glasby, Christopher J.; Ribeiro, Rannyele P.; Nakamura, Mayuko; Oguchi, Kohei; Omori, Akihito; Kohtsuka, Hisanori; Fischer, Christian; Ise, Yuji; Jimi, Naoto; Miura, Toru (Springer, 2022-01-19)
      Among over 20,000 species of Annelida, only two branching species with a highly modified body-pattern are known until now: the Syllidae Syllis ramosa McIntosh, 1879, and Ramisyllis multicaudata Glasby et al. (Zoological ...
    • Common environmental pollutants negatively affect development and regeneration in the sea anemone Nematostella vectensis holobiont 

      Klein, Sylvia; Frazier, Victoria; Readdean, Timothy; Lucas, Emily; Diaz-Jimenez, Erica P.; Sogin, Mitchell L.; Ruff, S. Emil; Echeverri, Karen (Frontiers Media, 2021-12-23)
      The anthozoan sea anemone Nematostella vectensis belongs to the phylum of cnidarians which also includes jellyfish and corals. Nematostella are native to United States East Coast marsh lands, where they constantly adapt ...
    • Uncovering the effects of symbiosis and temperature on coral calcification 

      Dellaert, Zoe; Vargas, Phillip A.; La Riviere, Patrick J.; Roberson, Loretta M. (University of Chicago Press, 2022-01-10)
      We tested the impact of temperature and symbiont state on calcification in corals, using the facultatively symbiotic coral Astrangia poculata as a model system. Symbiotic and aposymbiotic colonies of A. poculata were reared ...
    • Adaptive proteome diversification by nonsynonymous A-to-I RNA editing in coleoid cephalopods 

      Shoshan, Yoav; Liscovitch-Brauer, Noa; Rosenthal, Joshua J. C.; Eisenberg, Eli (Oxford University Press, 2021-05-22)
      RNA editing by the ADAR enzymes converts selected adenosines into inosines, biological mimics for guanosines. By doing so, it alters protein-coding sequences, resulting in novel protein products that diversify the proteome ...
    • Machine-learning-based evaluation of intratumoral heterogeneity and tumor-stroma interface for clinical guidance 

      Laurinavicius, Arvydas; Rasmusson, Allan; Plancoulaine, Benoit; Shribak, Michael; Levenson, Richard (Elsevier, 2021-09-21)
      Assessment of intratumoral heterogeneity and tumor-host interaction within the tumor microenvironment is becoming increasingly important for innovative cancer therapy decisions because of the unique information it can ...
    • Synuclein regulates synaptic vesicle clustering and docking at a vertebrate synapse 

      Fouke, Kaitlyn E.; Wegman, M. Elizabeth; Weber, Sarah A.; Brady, Emily B.; Román-Vendrell, Cristina; Morgan, Jennifer R. (Frontiers Media, 2021-11-26)
      Neurotransmission relies critically on the exocytotic release of neurotransmitters from small synaptic vesicles (SVs) at the active zone. Therefore, it is essential for neurons to maintain an adequate pool of SVs clustered ...
    • Survival and axonal outgrowth of the Mauthner cell following spinal cord crush does not drive post-injury startle responses 

      Zottoli, Steven J.; Faber, Donald S.; Hering, John; Dannhauer, Ann C.; Northen, Susan (Frontiers Media, 2021-11-19)
      A pair of Mauthner cells (M-cells) can be found in the hindbrain of most teleost fish, as well as amphibians and lamprey. The axons of these reticulospinal neurons cross the midline and synapse on interneurons and motoneurons ...
    • Swimming kinematics and performance of spinal transected lampreys with different levels of axon regeneration 

      Fies, Jacob; Gemmell, Brad J.; Fogerson, Stephanie M.; Morgan, Jennifer R.; Tytell, Eric D.; Colin, Sean P. (The Company of Biologists, 2021-11-05)
      Axon regeneration is critical for restoring neural function after spinal cord injury. This has prompted a series of studies on the neural and functional recovery of lampreys after spinal cord transection. Despite this, ...
    • Deep learning is widely applicable to phenotyping embryonic development and disease 

      Naert, Thomas; Çiçek, Özgün; Ogar, Paulina; Bürgi, Max; Shaidani, Nikko-Ideen; Kaminski, Michael M.; Xu, Yuxiao; Grand, Kelli; Vujanovic, Marko; Prata, Daniel; Hildebrandt, Friedhelm; Brox, Thomas; Ronneberger, Olaf; Voigt, Fabian F.; Helmchen, Fritjof; Loffing, Johannes; Horb, Marko E.; Rankin Willsey, Helen; Lienkamp, Soeren S. (The Company of Biologists, 2021-11-05)
      Genome editing simplifies the generation of new animal models for congenital disorders. However, the detailed and unbiased phenotypic assessment of altered embryonic development remains a challenge. Here, we explore how ...
    • The Nereid on the rise: Platynereis as a model system 

      Ozpolat, B. Duygu; Randel, Nadine; Williams, Elizabeth A.; Bezares-Calderón, Luis Alberto; Andreatta, Gabriele; Balavoine, Guillaume; Bertucci, Paola Y.; Ferrier, David E. K.; Gambi, Maria Cristina; Gazave, Eve; Handberg-Thorsager, Mette; Hardege, Jörg; Hird, Cameron; Hsieh, Yu-Wen; Hui, Jerome; Mutemi, Kevin Nzumbi; Schneider, Stephan Q.; Simakov, Oleg; Vergara, Hernando M.; Vervoort, Michel; Jékely, Gáspár; Tessmar-Raible, Kristin; Raible, Florian; Arendt, Detlev (BMC, 2021-09-27)
      The Nereid Platynereis dumerilii (Audouin and Milne Edwards (Annales des Sciences Naturelles 1:195–269, 1833) is a marine annelid that belongs to the Nereididae, a family of errant polychaete worms. The Nereid shows a ...